Glomerular collapse associated with subtotal renal infarction in kidney transplant recipients with multiple renal arteries
| Autor: | Julien Zuber, Marc-Olivier Timsit, Laure-Hélène Noël, Dany Anglicheau, Patrick Bruneval, Frank Martinez, Eric Thervet, Guillaume Canaud, Jean-Michel Correas, Vincent Audard, Marion Rabant, Christophe Legendre, Lara Zafrani, Natacha Patey |
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| Rok vydání: | 2009 |
| Předmět: |
Nephrology
Adult Male medicine.medical_specialty Pathology Renal glomerulus Kidney Glomerulus Kidney Nephropathy Podocyte Internal medicine medicine.artery medicine Humans Renal artery business.industry Podocytes Glomerulonephritis Middle Aged medicine.disease Kidney Transplantation medicine.anatomical_structure Infarction Female Kidney Diseases business Kidney disease |
| Zdroj: | American journal of kidney diseases : the official journal of the National Kidney Foundation. 55(3) |
| ISSN: | 1523-6838 |
| Popis: | Collapsing glomerulopathy is an aggressive kidney disease with rapid progression toward end-stage renal disease. Rare cases of de novo collapsing glomerulopathy have been reported during the post-transplant course and, in some instances, have been associated with renal graft vascular lesions. This finding raises the important question of whether ischemia could induce podocyte transdifferentiation, a hypothesis supported by evidence of hypoxia-inducible factor-dependent podocyte proliferation in HIV-associated nephropathy. We describe here 3 HIV-negative kidney transplant recipients in whom early graft biopsy performed in the vicinity of segmental graft infarction disclosed the typical features of glomerular collapse. Podocyte transdifferentiation was characterized by hallmark lesions, such as loss of mature podocyte phenotype, podocyte proliferation, and acquisition of a macrophage-like phenotype. Together, these data suggest that acute glomerular ischemia may lead to glomerular collapse in kidney transplants. |
| Databáze: | OpenAIRE |
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