Comparative Effect of Statins and Omega-3 Supplementation on Cardiovascular Events: Meta-Analysis and Network Meta-Analysis of 63 Randomized Controlled Trials Including 264,516 Participants
Autor: | Tung Hoang, Jeongseon Kim |
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Rok vydání: | 2020 |
Předmět: |
Male
medicine.medical_specialty Statin medicine.drug_class Atorvastatin Network Meta-Analysis Myocardial Infarction lcsh:TX341-641 Coronary Disease Cardiovascular event Disease 030204 cardiovascular system & hematology Article law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Internal medicine Fatty Acids Omega-3 medicine Humans cardiovascular diseases 030212 general & internal medicine Myocardial infarction Stroke Aged Pravastatin Randomized Controlled Trials as Topic Nutrition and Dietetics business.industry statin Middle Aged medicine.disease Treatment Outcome Cardiovascular Diseases Relative risk Dietary Supplements Cardiology Female Hydroxymethylglutaryl-CoA Reductase Inhibitors omega-3 business lcsh:Nutrition. Foods and food supply Food Science medicine.drug |
Zdroj: | Nutrients Volume 12 Issue 8 Nutrients, Vol 12, Iss 2218, p 2218 (2020) |
ISSN: | 2072-6643 |
Popis: | Statins and omega-3 supplementation have been recommended for cardiovascular disease prevention, but comparative effects have not been investigated. This study aimed to summarize current evidence of the effect of statins and omega-3 supplementation on cardiovascular events. A meta-analysis and a network meta-analysis of 63 randomized controlled trials were used to calculate pooled relative risks (RRs) and 95% confidence intervals (CIs) for the effects of specific statins and omega-3 supplementation compared with controls. Overall, the statin group showed significant risk reductions in total cardiovascular disease, coronary heart disease, myocardial infarction, and stroke however, omega-3 supplementation significantly decreased the risks of coronary heart disease and myocardial infarction only, in the comparison with the control group. In comparison with omega-3 supplementation, pravastatin significantly reduced the risks of total cardiovascular disease (RR = 0.81, 95% CI = 0.72&ndash 0.91), coronary heart disease (RR = 0.75, 95% CI = 0.60&ndash 0.94), and myocardial infarction (RR = 0.71, 95% CI = 0.55&ndash 0.94). Risks of total cardiovascular disease, coronary heart disease, myocardial infarction, and stroke in the atorvastatin group were statistically lower than those in the omega-3 group, with RRs (95% CIs) of 0.80 (0.73&ndash 0.88), 0.64 (0.50&ndash 0.82), 0.75 (0.60&ndash 0.93), and 0.81 (0.66&ndash 0.99), respectively. The findings of this study suggest that pravastatin and atorvastatin may be more beneficial than omega-3 supplementation in reducing the risk of total cardiovascular disease, coronary heart disease, and myocardial infarction. |
Databáze: | OpenAIRE |
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