Exploring the iron metabolism in multidrug resistant tuberculosis (MDR-TB) patients in treatment
| Autor: | S. Meite, Allico Joseph Djaman, G.A. Bahi, A.P. Bidie |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification medicine.medical_specialty Iron metabolism disorder Tuberculosis medicine.diagnostic_test biology Transferrin saturation Chemistry Anemia 030106 microbiology Iron Metabolism serum iron transferrin ferritin MDR-TB medicine.disease Ferritin 03 medical and health sciences Endocrinology Total iron-binding capacity Transferrin Internal medicine Immunology medicine biology.protein Serum iron |
| Zdroj: | International Journal of Biological and Chemical Sciences; Vol 11, No 3 (2017); 1039-1045 |
| ISSN: | 1991-8631 1997-342X 1039-1045 |
| Popis: | The iron metabolism plays a key role in the progression of active Tuberculosis. Several studies have shown a link between iron metabolism disorders an active tuberculosis. The aim of this study was to explore the iron metabolism of 100 patients with multidrug-resistant tuberculosis (MDR-TB) treated with second generation anti-tuberculosis drugs. The levels of iron in serum were assessed using atomic absorption spectrometry (AAS) while ferritin and transferrin were determined by imminoturbidimetry methods. The total iron binding capacity and transferrin saturation coefficient were determined from the values of transferrin and iron in the serum. The data showed a significant decrease in values of serum iron and total iron binding capacity (TIBC), in contrast to ferritin and the coefficient of transferrin saturation (CTS) which were in normal range before or after 6 months of treatment. These results are characteristic of inflammatory anemia. The persistence of this anemia despite treatment requires effective management of the inflammatory process in parallel with the use of second line anti-TB drugs. Keywords : Iron Metabolism, serum iron, transferrin, ferritin, MDR-TB. |
| Databáze: | OpenAIRE |
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