Normal 25-Hydroxyvitamin D Levels Are Associated with Less Proteinuria and Attenuate Renal Failure Progression in Children with CKD

Autor:	Shroff R., Aitkenhead H., Costa N., Trivelli A., Litwin M., Picca S., Anarat A., Sallay P., Ozaltin F., Zurowska A., Jankauskiene A., Montini G., Charbit M., Schaefer F., Wühl E., Bakkaloglu A., Peco-Antic A., Querfeld U., Gellermann J., Drozdz D., Bonzel K.-E., Wingen A.-M., Balasz I., Perfumo F., Müller-Wiefel D.E., Möller K., Offner G., Enke B., Gimpel C., Mehls O., Emre S., Caliskan S., Mir S., Wygoda S., Hohbach-Hohenfellner K., Jeck N., Klaus G., Ardissino G., Testa S., Niaudet P., Caldas-Afonso A., Fernandes-Teixeira A., Duek J., Matteucci M.C., Mastrostefano A., Wigger M., Berg U.B., Celsi G., Fischbach M., Terzic J., Fydryk J., Urasinski T., Coppo R., Peruzzi L., Arbeiter K., Jankauskiené A., Grenda R., Janas R., Laube G., Neuhaus T.J.
Přispěvatelé:	Çukurova Üniversitesi, Çocuk Sağlığı ve Hastalıkları, Ege Üniversitesi
Jazyk:	angličtina
Rok vydání:	2016
Předmět:	Male Vitamin medicine.medical_specialty Adolescent Medizin 030232 urology & nephrology Diastole Renal function Angiotensin-Converting Enzyme Inhibitors 030204 cardiovascular system & hematology urologic and male genital diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Clinical Research Reference Values Internal medicine Renin–angiotensin system medicine Vitamin D and neurology Humans Renal Insufficiency Renal Insufficiency Chronic Vitamin D Child Klotho Retrospective Studies Creatinine Proteinuria business.industry ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS General Medicine Urology & Nephrology ComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMS Fibroblast Growth Factor-23 ComputingMethodologies_PATTERNRECOGNITION Endocrinology chemistry Nephrology Disease Progression Female InformationSystems_MISCELLANEOUS medicine.symptom business
Popis:	PubMed ID: 26069294 Angiotensin-converting enzyme inhibitors (ACEi) for renin-angiotensin-aldosterone system (RAAS) blockade are routinely used to slow CKD progression. However, Vitamin D may also promote renoprotection by suppressing renin transcription through cross-talk between RAAS and Vitamin D -fibroblast growth factor-23 (FGF-23)-Klotho pathways. To determine whether Vitamin D levels influence proteinuria and CKD progression in children, we performed a post hoc analysis of the Effect of Strict Blood Pressure Control and ACE Inhibition on Progression of CKD in Pediatric Patients (ESCAPE) cohort. In 167 children (median EGFR 51 ml/min per 1.73 m2), serum 25-hydroxyvitaminD(25(OH)D),FGF-23, andKlotho levelsweremeasuredatbaselineandafteramedian8months onACEi.Childrenwith lower 25(OH)D levels had higher urinary protein/creatinine ratios at baseline (P=0.03) and at follow-up (P=0.006). Levels of 25(OH)D and serum Vitamin D -binding protein were not associated, but 25(OH)D #50 nmol/L associated with higher diastolicBP(P=0.004).ACEi therapy alsoassociatedwith increasedKlotho levels (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a2f4a400353e4143ca2eeecedc81649 https://hdl.handle.net/20.500.12605/17986