In vitrocharacterizations of mesoporous hydroxyapatite as a controlled release delivery device for VEGF in orthopedic applications
| Autor: | Tan Hc, Tee Yong Lim, Joachim Say Chye Loo, Wilson Wang, Chye Khoon Poh, Suxiu Ng |
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| Přispěvatelé: | School of Materials Science & Engineering |
| Rok vydání: | 2012 |
| Předmět: |
Vascular Endothelial Growth Factor A
Materials science Biomedical Engineering Neovascularization Physiologic Osseointegration Biomaterials chemistry.chemical_compound Humans Bone regeneration Cells Cultured Metals and Alloys Implant failure Cell Differentiation Mesenchymal Stem Cells Controlled release Engineering::Materials [DRNTU] Vascular endothelial growth factor Durapatite chemistry Transmission electron microscopy Delayed-Action Preparations Ceramics and Composites Implant Mesoporous material Porosity Biomedical engineering |
| Zdroj: | Journal of Biomedical Materials Research Part A. :3143-3150 |
| ISSN: | 1549-3296 |
| DOI: | 10.1002/jbm.a.34252 |
| Popis: | Following bone implant surgery, prolonged ischemic conditions at the implant site often result in postsurgical complications like failure of osseointegration at the bone-implant interface which can lead to implant failure. Thus, restoration of the vascular supply is paramount to the proper development of the bone. High surface area mesostructured materials have been shown to be attractive candidates for bone regeneration to enhance cell adhesion and cell proliferation. This study uses hydroxyapatite, a naturally occurring mineral in the bone, fabricated to a range of suitable pore sizes, infused with vascular endothelial growth factor (VEGF), to be progressively released to stimulate revascularization. In this study, several characterizations including nitrogen adsorption analysis, Fourier-transformed infrared spectroscopy, X-ray diffraction, field emission scanning electron microscope, and transmission electron microscope were used to evaluate the synthesized mesoporous hydroxyapatite (MHA). The results showed that MHA can gradually release VEGF for enhancing revascularization, which is beneficial for orthopedic applications. |
| Databáze: | OpenAIRE |
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