PMN cell counts and phagocytic activity of highly trained athletes depend on training period
| Autor: | Volker Hack, H. Weicker, M. Weiss, Günther Strobel |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Adult
Male medicine.medical_specialty Epinephrine Neutrophils Physiology Cell Running Leukocyte Count Norepinephrine chemistry.chemical_compound Phagocytosis Physiology (medical) Internal medicine medicine Humans Ingestion Graded exercise test Inverse correlation Training period Polymorphonuclear leukocyte Physical Education and Training Superoxide Oxygen Endocrinology medicine.anatomical_structure Microscopy Fluorescence chemistry Immunology medicine.drug |
| Zdroj: | Journal of Applied Physiology. 77:1731-1735 |
| ISSN: | 1522-1601 8750-7587 |
| Popis: | We tested the hypothesis that polymorphonuclear leukocyte (PMN) cell counts and phagocytic activity determined by latex ingestion and superoxide anion production are influenced by different training periods. We investigated long-distance runners before and up to 24 h after a graded exercise test to exhaustion during moderate training (MT) and intense training (IT) and compared them with untrained (control) subjects. Cell counts and phagocytic activity at rest and after exercise did not differ significantly between MT and control. On the contrary, IT showed a significant (P < or = 0.05) decrease in PMN cell count at rest (2.55 +/- 0.3 cells/nl) compared with MT (3.63 +/- 0.2 cells/nl) and control (3.41 +/- 0.8 cells/nl). Furthermore, phagocytic activity was significantly reduced (P < or = 0.05) in IT at rest and after exercise compared with MT and control. A strong inverse correlation (r = -0.75; P < or = 0.01) between epinephrine and superoxide anion production was found. These results provide evidence that the phagocytic activity depends on the training period and indicate impaired PMN functions during IT, which might lead to increased susceptibility to infection. |
| Databáze: | OpenAIRE |
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