E. coli outbreak in a neonate intensive care unit in a general hospital in Mexico City
| Autor: | Sara Arroyo-Escalante, Rigoberto Hernández-Castro, David Moncada-Barron, Juan Xicohtencatl-Cortes, Erika M. Carrillo-Casas, Zaydy Suástegui-Urquijo, Armando Navarro-Ocaña, Rosario Morales-Espinosa, Lorena Hernández-Delgado, José Luis Méndez-Sánchez, Angel Manjarrez-Hernandez, Gabriela Delgado-Sapién |
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| Rok vydání: | 2012 |
| Předmět: |
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Serotype medicine.medical_specialty medicine.medical_treatment Microbial Sensitivity Tests Hospitals General Microbiology Disease Outbreaks law.invention Serology Sepsis law Intensive Care Units Neonatal Intensive care Internal medicine Drug Resistance Bacterial Escherichia coli Pulsed-field gel electrophoresis Humans Medicine Mexico Escherichia coli Infections Cross Infection business.industry Infant Newborn Infant Outbreak General Medicine medicine.disease Intensive care unit Electrophoresis Gel Pulsed-Field Female business Infant Premature Central venous catheter |
| Zdroj: | Folia Microbiologica. 58:229-234 |
| ISSN: | 1874-9356 0015-5632 |
| DOI: | 10.1007/s12223-012-0202-x |
| Popis: | Nosocomial infections are a major cause of morbidity and mortality among neonates admitted to neonatal intensive care units (NICUs). The aim of this paper was to describe an outbreak of Escherichia coli among infants admitted to the NICU of the General Hospital "Dr. Manuel Gea Gonzalez" in May of 2008. The isolated E. coli strains were identified using standard biochemical methods. The susceptibilities of these strains were analysed by determining their minimal inhibitory concentrations. Following this, their molecular relationships to each other were assessed by pulsed field gel electrophoresis (PFGE) analysis and corroborated by serology. Twelve E. coli strains were isolated from blood, urine, or indwelling catheter samples from five cases of preterm infants within a 3-day period. Patients were admitted to the NICU of the general hospital and, during the outbreak, developed sepsis caused by E. coli. For four of the patients, the average age was 23 days, while one patient was a 3-month-old infant. Prior to sepsis, the infants had received assisted ventilation and hyperalimentation through a central venous catheter. Two profiles were observed by PFGE; profile A was identified as the outbreak's cause and an outcome of cross-infection, while profile B showed genetic differences but serologically it was identified as part of the same serotype. We conclude that E. coli colonised the patients through horizontal transmission. A focal source of the microorganism in this outbreak was not identified, but cross-transmission through handling was the most probable route. |
| Databáze: | OpenAIRE |
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