No association of single nucleotide polymorphisms involved in GHRL and GHSR with cancer risk: A meta-analysis
| Autor: | Yaoyao Hao, Shengjie Zhu, Bin Shao, Zongxian Li, Kai Wang, Houqiang Liu, Ming Wang, Hong Li |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Risk Oncology Cancer Research medicine.medical_specialty Colorectal cancer Single-nucleotide polymorphism Bioinformatics Polymorphism Single Nucleotide Breast cancer Neoplasms Internal medicine Genetics medicine Humans SNP Genetic Predisposition to Disease Receptors Ghrelin Aged business.industry Cancer General Medicine Odds ratio Middle Aged Esophageal cancer medicine.disease Ghrelin Case-Control Studies Meta-analysis business |
| Zdroj: | Cancer Biomarkers. 15:89-97 |
| ISSN: | 1875-8592 1574-0153 |
| DOI: | 10.3233/cbm-140441 |
| Popis: | BACKGROUND: Ghrelin was associated with several of cancers. The conflict results of SNPs with GHRL and GHSR gene were demonstrated in different studies. Thus, this meta-analysis is to evaluate the associations. METHODS: Systematic literature search was done on PubMed database up to October 2013. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association by a fixed-effect model and a random-effect model. RESULTS:A total of 7 studies, which included 3 studies for breast cancer, 2for colorectal cancer, 1 for hepatocellular carcinoma, 1 for esophageal cancer and 1 for Non-Hodgkin lymphoma. When analyzed all the GHRL SNPs with all kinds of cancers, there was significantly difference with cancer patients compared with controls (Recessive model: OR 0.938, 95% CI 0.890–0.989, p = 0.017), while no significant difference was existed in the additive model (OR 0.9903, 95% CI 0.957–1.024, p = 0.558) and dominant model (OR 1.014, 95% CI 0.970–1.061, p = 0.536). When analyzed all the GHSR SNPs with all kinds of cancers, no significant difference was observed. CONCLUSION: Our results suggest that the SNP with GHRL and GHSR might be weaker association with cancer risk, especially with breast cancer risk. |
| Databáze: | OpenAIRE |
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