Streptozotocin-induced diabetes selectively enhances antinociception mediated by δ1-but not δ2-opioid receptors
| Autor: | Yutaka Kasuya, Junzo Kamei, Hiroshi Nagase, Miwa Misawa, Yuriko Iwamoto |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Enkephalin medicine.drug_class Receptors Opioid mu Benzylidene Compounds Streptozocin General Biochemistry Genetics and Molecular Biology Diabetes Mellitus Experimental Mice Opioid receptor Receptors Opioid delta Internal medicine medicine Animals General Pharmacology Toxicology and Pharmaceutics Receptor Mice Inbred ICR Chemistry Antagonist Enkephalins General Medicine Streptozotocin Naltrexone Nociception Endocrinology Opioid Naltriben Analgesia Enkephalin D-Penicillamine (2 5) Oligopeptides medicine.drug |
| Zdroj: | Life Sciences. 55:PL121-PL126 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/0024-3205(94)90062-0 |
| Popis: | We assessed the effect of diabetes on antinociception produced by intracerebroventricular injection of δ-opioid receptor agonists [D-Pen 2,5 ]enkephalin (DPDPE) and [D-Ala 2 ]deltorphin II. The antinociceptive effect of DPDPE (10 nmol), administered i.c.v., was significantly greater in diabetic mice than in non-diabetic mice. The antinociceptive effect of i.c.v. DPDPE was significantly reduced in both diabetic and non-diabetic mice following pretreatment with 7-benzylidenenaltrexone (BNTX), a selective δ 1 -opioid receptor antagonist, but not with naltriben (NTB), a selective δ 2 - opioid receptor antagonist. There were no significant differences in the anticiceptive effect of [D-Ala 2 ]deltorphin II (3 nmol, i.c.v.) in diabetic and non-diabetic mice. Furthermore, the antinociceptive effect of i.c.v. [D-Ala 2 ]deltorphin II was significantly reduced in both diabetic and non-diabetic mice following pretreatment with NTB, but not with BNTX. In conclusion, mice with diabetes are selectively hyper-responsive to supraspinal δ 1 -opioid receptor-mediated antinociception, but are normally responsive to activation of δ 2 -opiod receptors. |
| Databáze: | OpenAIRE |
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