Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation
| Autor: | Glenn S. Van Aller, Peter J. Tummino, BaoChau Le, Gloria Mas, Roland S. Annan, Ryan G. Kruger, Patrick McDevitt, Nicolas Reynoird, Olena Barbash, Michael J. Huddleston, Or Gozani, Julien Sage, Shichong Liu, Benjamin A. Garcia, Robert H. Sinnamon, Anne-Flore Zmoos |
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| Přispěvatelé: | Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire [Grenoble] (CHU)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA) |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Cancer Research
[SDV]Life Sciences [q-bio] Blotting Western Biology Methylation Chromatin remodeling Substrate Specificity Histones Histone H4 Mice Histone H1 Peptide Library oncogene Smyd3 Histone methylation Histone H2A Animals Humans cancer Histone code RNA Small Interfering Molecular Biology ComputingMilieux_MISCELLANEOUS Mice Knockout lysine epigenetics Brief Report Genetic Complementation Test EZH2 Histone-Lysine N-Methyltransferase Fibroblasts Chromatin Recombinant Proteins 3. Good health Enzyme Activation Gene Expression Regulation Neoplastic Mice Inbred C57BL Phenotype Biochemistry Histone methyltransferase oncology Mutagenesis Site-Directed HeLa Cells Plasmids |
| Zdroj: | Epigenetics Epigenetics, Taylor & Francis, 2014, 7 (4), pp.340-343. ⟨10.4161/epi.19506⟩ |
| ISSN: | 1559-2294 1559-2308 |
| Popis: | Smyd3 is a lysine methyltransferase implicated in chromatin and cancer regulation. Here we show that Smyd3 catalyzes histone H4 methylation at lysine 5 (H4K5me). This novel histone methylation mark is detected in diverse cell types and its formation is attenuated by depletion of Smyd3 protein. Further, Smyd3-driven cancer cell phenotypes require its enzymatic activity. Thus, Smyd3, via H4K5 methylation, provides a potential new link between chromatin dynamics and neoplastic disease. |
| Databáze: | OpenAIRE |
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