Perspectives of Autologous Mesenchymal Stem-Cell Transplantation in Macular Hole Surgery: A Review of Current Findings
| Autor: | Nuzzi, R., Tridico, F., Azzolini, C. |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Pars plana genetic structures medicine.medical_treatment Vitrectomy Review Article Bioinformatics Surgical failure 03 medical and health sciences 0302 clinical medicine lcsh:Ophthalmology Medicine Macular hole business.industry Internal limiting membrane Mesenchymal stem cell Functional recovery medicine.disease eye diseases Transplantation Ophthalmology 030104 developmental biology medicine.anatomical_structure lcsh:RE1-994 030221 ophthalmology & optometry sense organs business |
| Zdroj: | Journal of Ophthalmology, Vol 2019 (2019) Journal of Ophthalmology |
| ISSN: | 2090-0058 |
| Popis: | The main treatment available for idiopathic macular holes is represented by pars plana vitrectomy with internal limiting membrane peeling. However, late-stage macular holes are affected by a higher risk of surgical failure. Although adjuvant techniques can be employed, a satisfactory functional recovery is difficult to achieve in refractory macular holes. Given their neuroprotective and antiapoptotic properties, mesenchymal stem cells (MSCs) may represent an appealing approach to treat these extreme cases. The purpose of this review is to highlight the findings regarding healing mechanisms exerted by mesenchymal stem cells and preliminary application in cases of refractory macular holes. When compared with MSCs, MSC-derived exosomes may represent a feasible alternative, given their reduced risk of undesired proliferation and easiness of use. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |