Effects of lesions of the ventral medial tegmentum on locomotor activity, biogenic amines and responses to amphetamine in rats
| Autor: | James L. Meyerhoff, G. Rufus Sessions, G. Jean Kant, George F. Koob |
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| Rok vydání: | 1980 |
| Předmět: |
Male
medicine.medical_specialty Biogenic Amines Serotonin Dextroamphetamine Time Factors Tegmentum Mesencephali Dopamine Clinical Biochemistry Hippocampal formation Motor Activity Toxicology Biochemistry Open field Behavioral Neuroscience chemistry.chemical_compound Norepinephrine Internal medicine medicine Tegmentum Animals Neurotransmitter Amphetamine Biological Psychiatry Pharmacology Rats Endocrinology chemistry medicine.drug |
| Zdroj: | Pharmacology, biochemistry, and behavior. 12(4) |
| ISSN: | 0091-3057 |
| Popis: | Rats subjected to electrolytic lesions of the ventral medial tegmentum (VMT) showed long-lasting increased locomotor activity in the open field compared to sham-operated controls. In addition to severe depletion of mesolimbic dopamine, the lesions also caused significant depletions of striatal dopamine, mesolimbic and striatal norepinephrine and striatal and hippocampal serotonin. Administration of d-amphetamine sulfate produced similar dose-response functions for locomotor activity in both VMT-lesioned and sham-operated rats despite the extensive depletion of dopamine in the VMT-lesioned rats. These results suggest that the mesolimbic dopamine pathway is not the sole substrate for amphetamine-stimulated locomotor activity. Electrolytic lesions of the VMT interrupt several neurotransmitter pathways which may produce complex and antagonistic effects on behavior. |
| Databáze: | OpenAIRE |
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