Probiotics: their action against pathogens can be turned around
| Autor: | Patrick Sorgeloos, Jingshu Liu, Yiying Liu, Junfeng Wu, Zhenhua Su, Jianhao Lin, Yuanyan Xiong, Jingjie Chen, Chuanhe Liu, Tom Defoirdt, Shijun Chen, Guo Qingqi, Wei-Hua Xu, Jijia Sun, Mengqiu Chen, Qiwei Qin, Weifang Wang, Zhaolin Lv, Willy Verstraete, Yuhui He, Jianwei Zheng, Yu Zhang, Gan Lian |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Science Danio Virulence Microbial communities Microbiology Genome Article law.invention Microbial ecology Fish Diseases 03 medical and health sciences Probiotic 0302 clinical medicine law Medicine and Health Sciences Metabolome Animals Metabolomics Microbiome Zebrafish Pathogen Bacterial genomics Vibrio Genetics Multidisciplinary Bacteria biology Microbiota Probiotics Bacterial pathogenesis biology.organism_classification 030104 developmental biology Vibrio Infections Medicine Disease Susceptibility Pathogens 030217 neurology & neurosurgery |
| Zdroj: | Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021) Scientific Reports SCIENTIFIC REPORTS |
| ISSN: | 2045-2322 |
| Popis: | Probiotics when applied in complex evolving (micro-)ecosystems, might be selectively beneficial or detrimental to pathogens when their prophylactic efficacies are prone to ambient interactions. Here, we document a counter-intuitive phenomenon that probiotic-treated zebrafish (Danio rerio) were respectively healthy at higher but succumbed at lower level of challenge with a pathogenic Vibrio isolate. This was confirmed by prominent dissimilarities in fish survival and histology. Based upon the profiling of the zebrafish microbiome, and the probiotic and the pathogen shared gene orthogroups (genetic niche overlaps in genomes), this consequently might have modified the probiotic metabolome as well as the virulence of the pathogen. Although it did not reshuffle the architecture of the commensal microbiome of the vertebrate host, it might have altered the probiotic-pathogen inter-genus and intra-species communications. Such in-depth analyses are needed to avoid counteractive phenomena of probiotics and to optimise their efficacies to magnify human and animal well-being. Moreover, such studies will be valuable to improve the relevant guidelines published by organisations such as FAO, OIE and WHO. |
| Databáze: | OpenAIRE |
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