Association of COMT gene variability with pain intensity in patients after total hip replacement

Autor:	Violetta Sulżyc-Bielicka, Anna Machoy-Mokrzyńska, Alina Jurewicz, Zuzanna Starzyńska-Sadura, Katarzyna Leźnicka, Krzysztof Safranow, Monika Białecka, Mateusz Kurzawski, Violetta Dziedziejko, Andrzej Bohatyrewicz
Rok vydání:	2019
Předmět:	Male medicine.medical_specialty Visual Analog Scale genetic structures Arthroplasty Replacement Hip Clinical Biochemistry Total hip replacement Pain Osteoarthritis Disease Catechol O-Methyltransferase Polymorphism Single Nucleotide behavioral disciplines and activities 03 medical and health sciences 0302 clinical medicine Gene Frequency 030202 anesthesiology Polymorphism (computer science) Internal medicine mental disorders medicine Humans Genetic Predisposition to Disease In patient Comt gene Association (psychology) Alleles Genetic Association Studies Aged business.industry General Medicine medicine.disease Intensity (physics) Haplotypes Multivariate Analysis Linear Models Female business 030217 neurology & neurosurgery
Zdroj:	Scandinavian Journal of Clinical and Laboratory Investigation. 79:202-207
ISSN:	1502-7686 0036-5513
DOI:	10.1080/00365513.2019.1576920
Popis:	Pain is one of the most interdisciplinary clinical symptoms of a disease. The aim of the study was to evaluate the association of COMT gene polymorphism with pain perception in patients after total hip replacement (THR). The study included 195 patients qualified for surgical treatment (THR) due to osteoarthritis. Patients previously undergoing hip replacement subsequently underwent multimodal pain management therapy, in accordance with the recommendations for treating postoperative pain. The intensity of pain was measured three times at pre-defined time intervals: 1.5, 6 and 12 months after hip replacement, using the visual analogue scale. Single nucleotide polymorphism (SNP) in the COMT gene rs4680: AG (Val158Met), rs6269: AG (promoter region), rs4633: CT (His62His) and rs4818: CG (Leu136Leu) was genotyped. COMT SNP frequency distribution was analysed. For rs6269 and rs4818, the minor allele was the G allele (38.7 and 38.5%, respectively). It was also observed that rs4633 (T) allele frequency (50%) equalled that of the rs4680 (A) allele (50%). We assessed COMT haplotype frequency in the patients studied. The most frequent haplotype was haplotype M (ATCA) (50%), the rarest haplotype was haplotype R (ATGG), with a frequency of 0.3%. The most frequent diplotype was H/M, which was found in 37.95% of the patients. The frequency of other diplotypes was: M/M-24.10%, H/H-15.90% and L/M-13.33%. The study showed a significant association of rs4818 G allele and equivalent COMT H haplotype with lower sensitivity to pain after hip replacement.
Databáze:	OpenAIRE
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