Management of the sensitized pediatric heart transplant patient
| Autor: | Erik L Frandsen, Erin L. Albers |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Heart transplantation
medicine.medical_specialty Pediatric transplant biology business.industry medicine.medical_treatment Human leukocyte antigen Review Article 030204 cardiovascular system & hematology 030230 surgery 03 medical and health sciences 0302 clinical medicine Increased risk medicine.anatomical_structure surgical procedures operative Pediatrics Perinatology and Child Health Epidemiology Immunology biology.protein medicine Transplant patient Antibody business Sensitization |
| Zdroj: | Translational pediatrics. 8(4) |
| ISSN: | 2224-4344 |
| Popis: | Despite advancements in transplant immunosuppression and techniques for managing critically ill patients awaiting heart transplantation, children who are immunologically sensitized to human leukocyte antigen remain at increased risk for morbidity and mortality, both while awaiting and after heart transplant. In this review we will discuss the epidemiology of sensitization, review the immunologic basis and methods of human leukocyte antigen antibody detection, describe outcomes for sensitized pediatric transplant candidates, and consider both pre- and post-transplant management options for sensitized patients. |
| Databáze: | OpenAIRE |
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