Transarterial chemoembolization combined with Huaier granule for the treatment of primary hepatic carcinoma: Safety and efficacy
| Autor: | Yue Wei Zhang, Guang Sheng Zhao, Qing Zhang, Chuang Li, Zhi Zhong Ren, Ying Liu, Ming Zhang, Jun Zhou |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Carcinoma Hepatocellular Time Factors Organoplatinum Compounds education Observational Study Antineoplastic Agents Kaplan-Meier Estimate Complex Mixtures behavioral disciplines and activities Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine Medicine Humans Chemoembolization Therapeutic Aged Trametes Gelatin sponge business.industry General Medicine Huaier Granule Middle Aged Combined Modality Therapy gelatin sponge particles 030104 developmental biology Treatment Outcome 030220 oncology & carcinogenesis Female Neoplasm Grading business Primary hepatic carcinoma hepatic carcinoma Cyclobutanes Huaier granule Drugs Chinese Herbal Follow-Up Studies Research Article transcatheter arterial chemoembolization |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 |
| Popis: | To evaluate the safety and efficacy of transarterial arterial chemoembolization (TACE) with gelatin sponge particles (GSPs-TACE) and Huaier granule to treat primary hepatic carcinoma (PHC). A series of 62 patients with PHC were included between June 2009 and December 2011, and randomly assigned to a control (n = 31) or an experimental group (n = 31). The control patients received TACE with 350 to 560 μm GSPs plus lobaplatin chemotherapy. Patients in the experimental group received TACE plus Huaier granule. Treatment safety and mid-to-long-term efficacy were evaluated. Follow-up ranged from 12 to 24 months with a mean of 28.7 months. The 6- and 12-month overall survivals were 100% and 93.5% in the experimental group and 90.3% and 80.6% in control group, respectively. The difference in overall survival at 12 months was significant (χ2 = 5.213, P .05). The number of TACE procedures in the experimental group (2.9 ± 8.7) and control group (4.1 ± 7.3) patients was significantly different (χ2 = 7.262, P |
| Databáze: | OpenAIRE |
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