Prevalence of dyslipidemia in statin-treated patients in the Baltic states (Estonia, Latvia, and Lithuania): results of the Dyslipidemia International Study (DYSIS)
| Autor: | Andrejs Erglis, Peter Bramlage, Rimvydas Šlapikas, Anete Gocentiene, Ene Mäeots, Margus Viigimaa, Gustavs Latkovskis, Philippe Brudi, Žaneta Petrulionienė |
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| Rok vydání: | 2014 |
| Předmět: |
Estonia
Male medicine.medical_specialty Multivariate analysis Statin medicine.drug_class Disease chemistry.chemical_compound High-density lipoprotein cholesterol Internal medicine medicine Prevalence Humans Low-density lipoprotein cholesterol Life Style Triglycerides Aged Dyslipidemias Medicine(all) lcsh:R5-920 Triglyceride Traditional medicine business.industry Cholesterol Statins nutritional and metabolic diseases Lithuania Middle Aged Cardiovascular disease medicine.disease Obesity Latvia Dyslipidemia chemistry Automotive Engineering lipids (amino acids peptides and proteins) Observational study Female Hydroxymethylglutaryl-CoA Reductase Inhibitors lcsh:Medicine (General) business |
| Zdroj: | Medicina; Volume 50; Issue 1; Pages: 44-53 Medicina, Vol 50, Iss 1, Pp 44-53 (2014) Medicina Volume 50 Issue 1 Pages 44-53 |
| ISSN: | 1648-9144 |
| Popis: | Background and objective: The Baltic nations (Estonia, Latvia, and Lithuania) are profoundly affected by cardiovascular disease (CVD). Studies have indicated that patients may experience persistent dyslipidemia despite chronic statin treatment. Therefore, the aim of this study was to analyze the risk factors for dyslipidemia despite statin-treatment in a large dataset from the Baltic nations.Material and methods: Patients in primary care centers across the Baltic nations were enrolled into the cross-sectional, observational Dyslipidemia International Study (DYSIS). Patients were ≥45 years old and had been treated with statins for at least three months. Patient characteristics and lipid measurements were used to determine variables contributing to dyslipidemia (abnormal low-density lipoprotein cholesterol [LDL-C], high-density lipopro- tein cholesterol [HDL-C], or total triglyceride [TG] values).Results: We enrolled 1797 patients with a mean age of 66.1 years and 59.1% being female. Overall 63.4% had cardiovascular disease, 30.1% were diabetic and 77.8% at high risk for cardiovascular complications. LDL-C was not at target level for 80.7% low HDL-C levels were observed for 26.0%, and elevated TG levels were found in 35.0% of all patients. Multivariate analyses indicated that a BMI ≥ 30 kg/m2 (OR, 2.12 95% CI, 1.45–3.08) and hypertension (OR, 2.43 95% CI, 1.1 6–5.10) were strongly associated with dyslipidemia (involving all three lipids) during statin therapy while age ≥70 years (OR, 0.63 95% CI, 0.42–0.94) and female gender (OR, 0.48 95% CI, 0.33–0.68) conferred reduced risk.Conclusions: Our findings indicate many statin-treated patients in Estonia, Latvia, and Lithuania did not meet target lipid levels and had a very high risk of CVD. Combating other well-known CVD risk factors such as obesity and hypertension is vital to reduce the exceptionally high riskfor CVD mortality seen in the Baltic nations. |
| Databáze: | OpenAIRE |
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