Production of large quantities of 90Y by ion-exchange chromatography using an organic resin and a chelating agent
| Autor: | Heyam Mukhallalati, Marylaine Pérez-Malo, Néstor Cornejo Díaz, Keila Isaac-Olivé, Abmel Xiques Castillo, Edgar Casanova Gonzalez, Mirta Torres Berdeguez |
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| Rok vydání: | 2009 |
| Předmět: |
Cancer Research
Chromatography Time Factors Tandem Ion exchange Chemistry Elution Ion chromatography Chromatography Ion Exchange Isotope separation law.invention Volumetric flow rate law Strontium Radioisotopes Molecular Medicine Radiology Nuclear Medicine and imaging Chelation Yttrium Radioisotopes Ion Exchange Resins Ion-exchange resin Edetic Acid Chelating Agents |
| Zdroj: | Nuclear medicine and biology. 37(8) |
| ISSN: | 1872-9614 |
| Popis: | The performance of a system composed of an organic cation exchanger (Dowex 50Wx8) and a chelating agent (EDTA) previously described for the successful production of (90)Y via a (90)Sr/(90)Y generator is assessed under dynamic conditions. In an attempt to overcome the established limitation of ion-exchange resins for the separation of subcurie quantities of activity, (90)Y is repeatedly isolated from an 11.8-GBq (320 mCi) (90)Sr cow using a three-column tandem arrangement. The high recovery and radionuclidic purity obtained for (90)Y and the parameters of the separation (time, eluant concentration, pH and flow rate range) strongly suggest that Ci quantities of (90)Y can be handled satisfactorily by the ion-exchange method. No replacement or treatment of the cow, low waste generation and (90)Sr losses less than 0.1% after each run were observed during the present study which, in combination with the low cost of this resin, may result in an attractive alternate method for the production of large quantities of (90)Y. |
| Databáze: | OpenAIRE |
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