Association between low maternal low-density lipoprotein cholesterol levels in the second trimester and delivery of small for gestational age infants at term: a case-control study of the national center for child health and development birth cohort
| Autor: | Atsushi Ogihara, Naoko Arata, Reiko Horikawa, Naoko Sakamoto, Kana Serizawa, Kohei Ogawa |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Term Birth Gestational Age Cohort Studies 03 medical and health sciences 0302 clinical medicine Pregnancy Odds Ratio medicine Humans 030212 general & internal medicine Risk factor reproductive and urinary physiology 030219 obstetrics & reproductive medicine Obstetrics business.industry Cholesterol HDL Infant Newborn Case-control study Obstetrics and Gynecology Gestational age medicine.disease Lipoproteins LDL Case-Control Studies Pregnancy Trimester Second Infant Small for Gestational Age Pediatrics Perinatology and Child Health Regression Analysis Small for gestational age Female business Full Term Birth Cohort study |
| Zdroj: | The Journal of Maternal-Fetal & Neonatal Medicine. 30:1383-1387 |
| ISSN: | 1476-4954 1476-7058 |
| DOI: | 10.1080/14767058.2016.1214701 |
| Popis: | Maternal malnutrition during pregnancy can lead to a small for gestational age (SGA) status among infants. In the present study, we compared the lipid levels during the second trimester in women who delivered SGA infants at term with those in women who delivered appropriate for gestational age infants at term, to examine whether abnormalities in maternal lipid levels could be a risk factor for the delivery of an SGA infant. We enrolled pregnant women who gave birth at the National Center for Child Health and Development (NCCHD), their infants, and who volunteered in a Birth cohort study at the NCCHD. We analyzed a total of 843 blood samples obtained from the women during the second trimester. Moreover, we used multi-regression analysis to assess the relationship between low-density lipoprotein cholesterol (LDL-C) levels during the second trimester and the risk of delivering an SGA infant. The adjusted odds ratio (OR) for LDL-C levels was 0.99 (95% CI, 0.98-0.99). These results indicate that a low LDL-C level during the second trimester was associated with an increased risk of delivering an SGA infant at term. The finding would not only help predict future SGA infant birth, but can also help prevent SGA infant birth. |
| Databáze: | OpenAIRE |
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