Deep inspiration-induced changes in lung volume decrease with severity of asthma

Autor: Nicola Scichilone, Vincenzo Bellia, Amelia Interrante, Roberto Marchese, Simona Soresi, Alkis Togias
Přispěvatelé: SCICHILONE N, MARCHESE R, SORESI S, INTERRANTE A, TOGIAS A, BELLIA V
Rok vydání: 2007
Předmět:
Adult
Male
Pulmonary and Respiratory Medicine
Allergy
medicine.medical_specialty
Adolescent
Vital Capacity
Bronchi
Settore MED/10 - Malattie Dell'Apparato Respiratorio
Gastroenterology
Severity of Illness Index
Bronchial Provocation Tests
Drug Administration Schedule
Lung inflation
Bronchoconstrictor Agents
03 medical and health sciences
FEV1/FVC ratio
0302 clinical medicine
Internal medicine
Forced Expiratory Volume
medicine
Outpatient clinic
Corticosteroids
Humans
Lung volumes
Albuterol
030212 general & internal medicine
asthma
deep inspiration
lung function
Methacholine Chloride
Asthma
Aged
Methacholine
business.industry
Respiratory disease
Middle Aged
medicine.disease
3. Good health
Bronchodilator Agents
030228 respiratory system
Inhalation
Anesthesia
Salbutamol
Bronchodilation
Female
business
medicine.drug
Zdroj: Respiratory Medicine. 101(5):951-956
ISSN: 0954-6111
DOI: 10.1016/j.rmed.2006.09.009
Popis: Summary We have previously reported that the magnitude of deep inspiration (DI)-induced bronchodilation is only slightly reduced in mild asthmatics, compared to healthy subjects. The aim of this study was to evaluate whether increased severity of asthma is associated with impairment in the ability of DI to induce changes in lung volume. Thirty-six consecutive asthmatics recruited from the Pulmonary and the Allergy Outpatient Clinics of the Institute of Respiratory Diseases of the University of Palermo were divided into 3 groups: Intermittent (I), Mild Persistent (MP) and Moderate–Severe (MS), based on GINA guidelines. Single dose methacholine (Mch) bronchoprovocations were performed in the absence of DI, to induce at least 15% reduction in inspiratory vital capacity (IVC) from baseline. The post-Mch IVC was followed by 4 consecutive DI and by another IVC, to determine the bronchodilatory effect of DI. The bronchodilatory effect of DI was found to significantly decrease with increasing severity of asthma (I: 68±5.4%, MP: 45±7.2%, MS: 4±15.6%; ANOVA: P 1 or FEV 1 /FVC, was also inversely correlated to symptom scores ( r = - 0.42 , P = 0.01 ) and to weekly salbutamol usage ( r = - 0.47 , P = 0.004 ). These observations provide support to the hypothesis that the attenuation of the bronchodilatory effect of DI contributes to the severity of the clinical manifestations of asthma.
Databáze: OpenAIRE
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