In vitro selection of mutants resistant to ozenoxacin compared with levofloxacin and ciprofloxacin in Gram-positive cocci
| Autor: | Paula Espinal, Rafael Cantón, Domingo Gargallo-Viola, Yuly López, Marta Tato, F. Garcia-Alonso, Jordi Vila |
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| Rok vydání: | 2014 |
| Předmět: |
DNA
Bacterial Microbiology (medical) medicine.drug_class Aminopyridines Levofloxacin Microbial Sensitivity Tests Quinolones medicine.disease_cause Polymerase Chain Reaction Microbiology Ciprofloxacin Drug Resistance Bacterial medicine Humans Pharmacology (medical) Selection Genetic Gram-Positive Cocci Gram-Positive Bacterial Infections Pharmacology Chemistry Broth microdilution Sequence Analysis DNA biochemical phenomena metabolism and nutrition Quinolone Anti-Bacterial Agents Infectious Diseases Streptococcus agalactiae Mutation Streptococcus pyogenes Ozenoxacin medicine.drug |
| Zdroj: | Journal of Antimicrobial Chemotherapy. 70:57-61 |
| ISSN: | 1460-2091 0305-7453 |
| DOI: | 10.1093/jac/dku375 |
| Popis: | OBJECTIVES To determine the frequency of selecting mutants resistant to ozenoxacin, a des-fluoro-(6)-quinolone active against pathogens involved in skin and skin structure infections, compared with levofloxacin and ciprofloxacin in quinolone-susceptible and -resistant Gram-positive cocci. METHODS Forty-nine quinolone-susceptible and -resistant Gram-positive cocci strains with different profiles of mutations in the quinolone resistance-determining region (QRDR) were examined to determine the frequency of selecting mutants resistant to ozenoxacin compared with levofloxacin and ciprofloxacin. MICs and mutations in the QRDR were determined by standard broth microdilution and PCR amplification and sequencing, respectively. RESULTS The mean resistance rates were 3.8 × 10(-9) (range |
| Databáze: | OpenAIRE |
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