Inhibition of FSH affects spermatogenesis in the mature ram
| Autor: | R.J. Kilgour, M.R. Sairam, M.P. Dubois, M. Courot, C. Pisselet |
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| Přispěvatelé: | ProdInra, Migration, Unité de recherche Physiologie de la reproduction des mammifères domestiques, Nouzilly, Institut National de la Recherche Agronomique (INRA) |
| Jazyk: | angličtina |
| Rok vydání: | 1993 |
| Předmět: |
endocrine system
medicine.medical_specialty [SDV]Life Sciences [q-bio] medicine.medical_treatment Biology [INFO] Computer Science [cs] Andrology 03 medical and health sciences Follicle-stimulating hormone 0302 clinical medicine Endocrinology Food Animals Meiosis Internal medicine FSH medicine Seasonal breeder [INFO]Computer Science [cs] Secretion Testosterone ComputingMilieux_MISCELLANEOUS 030304 developmental biology 0303 health sciences 030219 obstetrics & reproductive medicine urogenital system Immunosuppression General Medicine Sertoli cell [SDV] Life Sciences [q-bio] medicine.anatomical_structure Animal Science and Zoology Spermatogenesis |
| Zdroj: | Animal Reproduction Science Animal Reproduction Science, Elsevier Masson, 1993, 32, pp.213-225 |
| ISSN: | 0378-4320 |
| Popis: | We examined the effect of immunosuppression of follicle stimulating hormone (FSH) on spermatogenesis in adult rams in the breeding season. Rams were immunised for 20 days with one of two anti-FSH antisera, AS1 (n=5) or AS2 (n=5) and spermatogenesis compared with that of control rams (n=4) treated with equine γ-globulins. Treatment with either AS1 or AS2 had no effect on the number of Sertoli cells or A0 spermatogonia per testis nor on the daily production of A1 spermatogonia or of spermatids. However, treatment with either AS1 or AS2 significantly decreased the nuclear size of the Sertoli cells, the daily production of B2 spermatogonia and of leptotene spermatocytes. Treatment with AS1 also decreased the daily production of pachytene spermatocytes. Neither anti-serum affected the secretion of testosterone or luteinising hormone (LH). This experiment has shown that FSH is necessary for normal spermatogenesis in the adult ram because, between the development from A1 to B2 spermatogonia, there exists a step which is sensitive to FSH deprivation. This effect is probably mediated through an impairment of Sertoli cell function. |
| Databáze: | OpenAIRE |
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