A single-centre observational study of surgery and late malignant events after chemotherapy for germ cell cancer
| Autor: | J. Ong, C. G. Fowler, R. T. D. Oliver, A. M. I. Paris, D. F. Badenoch, W.F. Hendry, R. Ravi |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Male medicine.medical_specialty Urology medicine.medical_treatment Antineoplastic Agents Disease Metastasis Retroperitoneal lymph node dissection Testicular Neoplasms medicine Humans Stage (cooking) Retrospective Studies Chemotherapy business.industry Incidence (epidemiology) Cancer Neoplasms Second Primary medicine.disease Seminoma Surgery Survival Rate Treatment Outcome medicine.anatomical_structure Germinoma Neoplasm Recurrence Local business Germ cell |
| Zdroj: | BJU International. 80:647-652 |
| ISSN: | 1464-410X 1464-4096 |
| DOI: | 10.1046/j.1464-410x.1997.00410.x |
| Popis: | Objective To review the impact of surgical staging after treatment on the late malignant events in an unselected group of patients treated with chemotherapy for germ cell cancer of the testis over the last 16 years. Patients and methods The study comprised 256 patients treated between 1978 and 1994 who were reviewed for late relapse and development of second germ cell and non-germ cell cancer. Results At diagnosis, 142 patients had clinical stage 2, 30 stage 3 and 84 stage 4 disease; 57 patients relapsed within 20 months of treatment, while late germ-cell cancer relapses (≥24 months after treatment) occurred in six patients. Of patients relapsing early or late, 42% and 33%, respectively, received surgery after treatment. Only two of those relapsing late remain progression-free with further treatment. Four patients developed germ cell cancer in the contralateral testis, while six developed second non-germ cell cancers. Conclusion Late events occurred in 6.2% of 256 patients in this series, from 29 to 141 months after treatment. Given that the late relapse rate of six of 256 (2.3%) is less than the incidence of mature teratoma at routine retroperitoneal lymph node dissection, more patients may eventually relapse. These results suggest that there might be a case to evaluate the use of ultrasonographic surveillance of the retroperitoneum and testis at 5, 10 and 20 years, in addition to extending routine surveillance. |
| Databáze: | OpenAIRE |
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