New mechanisms of CCR5-Δ32 carriers' advantage – Impact on progenitor cells and renal function
| Autor: | Piotr Gutknecht, Monika Ryba-Stanisławowska, Urszula Ławrynowicz, Bartosz Słomiński, Maria Skrzypkowska, Janusz Siebert |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Heterozygote medicine.medical_specialty Receptors CCR5 Endothelium CD34 Biology Kidney Cardiovascular System Biochemistry CXCR4 03 medical and health sciences Chemokine receptor 0302 clinical medicine Gene Frequency Internal medicine medicine Humans Genetic Predisposition to Disease Allele Progenitor cell Polymorphism Genetic Stem Cells Wild type Cell Biology Middle Aged 030104 developmental biology medicine.anatomical_structure Endocrinology Case-Control Studies 030220 oncology & carcinogenesis Hypertension Female Homeostasis |
| Zdroj: | The International Journal of Biochemistry & Cell Biology. 108:92-97 |
| ISSN: | 1357-2725 |
| DOI: | 10.1016/j.biocel.2019.01.006 |
| Popis: | Background CCR5 is a chemokine receptor expressed by various populations including leukocytes, smooth muscle cells and endothelium. Δ32 polymorphism of CCR5 gene has been connected with, inter alia, cardiovascular disease development. The aim of our study was to evaluate impact of CCR5 variant on CD34+ and CD34+VEGFR2+ cells - populations involved in cardiovascular system homeostasis and regeneration. Methods and results We have examined 170 Polish subjects from Pomeranian region. The analysis concerned CCR5 polymorphism and flow cytometry evaluation of whole blood cells. Our results indicate that individuals with at least one CCR5-Δ32 allele are characterized by greater number of CD34+CXCR4+, CD34+VEGFR2+ and CD34+VEGFR2+c-Kit + cells than their wild type counterparts. This group also exhibits more beneficial values of renal function parameters. Conclusion Maintaining greater size of CD34+ and CD34+VEGFR2+ populations as well as proper kidney function may constitute mechanisms that connect chemokine receptor polymorphism with cardiovascular system health. |
| Databáze: | OpenAIRE |
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