Validation of electronic health record phenotyping of bipolar disorder cases and controls
| Autor: | Victor M, Castro, Jessica, Minnier, Shawn N, Murphy, Isaac, Kohane, Susanne E, Churchill, Vivian, Gainer, Tianxi, Cai, Alison G, Hoffnagle, Yael, Dai, Stefanie, Block, Sydney R, Weill, Mireya, Nadal-Vicens, Alisha R, Pollastri, J Niels, Rosenquist, Sergey, Goryachev, Dost, Ongur, Pamela, Sklar, Roy H, Perlis, Jordan W, Smoller, Richard A, Belliveau |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Bipolar Disorder MEDLINE Sensitivity and Specificity Article Cohort Studies Electronic health record Predictive Value of Tests Health care medicine Electronic Health Records Humans Medical physics Bipolar disorder Medical diagnosis Psychiatry Aged Natural Language Processing business.industry Reproducibility of Results Middle Aged Control subjects medicine.disease Psychiatry and Mental health Phenotype Predictive value of tests Case-Control Studies Female business Algorithms Cohort study |
| Zdroj: | The American journal of psychiatry. 172(4) |
| ISSN: | 1535-7228 |
| Popis: | The study was designed to validate use of electronic health records (EHRs) for diagnosing bipolar disorder and classifying control subjects.EHR data were obtained from a health care system of more than 4.6 million patients spanning more than 20 years. Experienced clinicians reviewed charts to identify text features and coded data consistent or inconsistent with a diagnosis of bipolar disorder. Natural language processing was used to train a diagnostic algorithm with 95% specificity for classifying bipolar disorder. Filtered coded data were used to derive three additional classification rules for case subjects and one for control subjects. The positive predictive value (PPV) of EHR-based bipolar disorder and subphenotype diagnoses was calculated against diagnoses from direct semistructured interviews of 190 patients by trained clinicians blind to EHR diagnosis.The PPV of bipolar disorder defined by natural language processing was 0.85. Coded classification based on strict filtering achieved a value of 0.79, but classifications based on less stringent criteria performed less well. No EHR-classified control subject received a diagnosis of bipolar disorder on the basis of direct interview (PPV=1.0). For most subphenotypes, values exceeded 0.80. The EHR-based classifications were used to accrue 4,500 bipolar disorder cases and 5,000 controls for genetic analyses.Semiautomated mining of EHRs can be used to ascertain bipolar disorder patients and control subjects with high specificity and predictive value compared with diagnostic interviews. EHRs provide a powerful resource for high-throughput phenotyping for genetic and clinical research. |
| Databáze: | OpenAIRE |
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