IL-37 Confers Protection against Mycobacterial Infection Involving Suppressing Inflammation and Modulating T Cell Activation
| Autor: | Wenjuan Bai, Xin He, Peng Wang, Hua Yang, Qun Ji, Haipeng Liu, Siyu Liu, Baoxue Ge, Wenxia Peng, Jianxia Chen, Zhonghua Liu, Hao Chen, Ruijuan Zheng |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Bacterial Diseases
0301 basic medicine Physiology lcsh:Medicine Pathology and Laboratory Medicine Lymphocyte Activation Pathogenesis White Blood Cells Mice Gene Frequency Animal Cells Immune Physiology Medicine and Health Sciences lcsh:Science Immune Response Cells Cultured Innate Immune System Multidisciplinary T Cells Animal Models Regulatory T cells Acquired immune system Mycobacterium bovis Actinobacteria Infectious Diseases medicine.anatomical_structure Experimental Organism Systems Cytokines Female Cellular Types medicine.symptom Research Article Immune Cells T cell Immunology Mouse Models Mice Transgenic Inflammation Spleen Biology Research and Analysis Methods Polymorphism Single Nucleotide Peripheral blood mononuclear cell Proinflammatory cytokine Mycobacterium tuberculosis 03 medical and health sciences Signs and Symptoms Model Organisms Diagnostic Medicine medicine Tuberculosis Animals Humans Genetic Predisposition to Disease Mycobacterium Infections Blood Cells Bacteria Macrophages lcsh:R Organisms Biology and Life Sciences Cell Biology Molecular Development Th1 Cells Tropical Diseases biology.organism_classification Mice Inbred C57BL 030104 developmental biology Cytoprotection Immune System Case-Control Studies Th17 Cells lcsh:Q Developmental Biology Interleukin-1 |
| Zdroj: | PLoS ONE, Vol 12, Iss 1, p e0169922 (2017) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Interleukin-37 (IL-37), a novel member of the IL-1 family, plays fundamental immunosuppressive roles by broadly reducing both innate inflammation and acquired immunity, but whether it is involved in the pathogenesis of tuberculosis (TB) has not been clearly elucidated. In this study, single nucleotide polymorphism (SNP) analysis demonstrated an association of the genetic variant rs3811047 of IL-37 with TB susceptibility. In line with previous report, a significant elevated IL-37 abundance in the sera and increased expression of IL-37 protein in the peripheral blood mononuclear cells (PBMC) were observed in TB patients in comparison to healthy controls. Moreover, release of IL-37 were detected in either macrophages infected with Mycobacterium tuberculosis (Mtb) or the lung of BCG-infected mice, concurrent with reduced production of proinflammatory cytokines including IL-6 and TNF-α. Furthermore, in contrast to wild-type mice, BCG-infected IL-37-Tg mice manifested with reduced mycobacterial burden and tissue damage in the lung, accompanied by higher frequency of Th1 cell and less frequencies of regulatory T cells and Th17 cells in the spleen. Taken together, our findings demonstrated that IL-37 conferred resistance to Mtb infection possibly involving suppressing detrimental inflammation and modulating T cell responses. These findings implicated that IL-37 may be employed as a new molecular target for the therapy and diagnosis of TB. |
| Databáze: | OpenAIRE |
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