The Protective Effect of N-Acetylcysteine on Ionizing Radiation Induced Ovarian Failure and Loss of Ovarian Reserve in Female Mouse
| Autor: | Jing-Yin Dong, Jin-Xiao Liang, Chi Ma, Wei Gao, Qiu Yan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty endocrine system Article Subject lcsh:Medicine Apoptosis Radiation-Protective Agents Ovary Primary Ovarian Insufficiency Biology Endometrium medicine.disease_cause General Biochemistry Genetics and Molecular Biology Acetylcysteine Mice 03 medical and health sciences 0302 clinical medicine Ovarian Follicle Radiation Ionizing Internal medicine medicine Animals Humans Embryo Implantation Ovarian follicle Ovarian Reserve Ovarian reserve Cell Proliferation General Immunology and Microbiology lcsh:R General Medicine Disease Models Animal 030104 developmental biology Endocrinology medicine.anatomical_structure 030220 oncology & carcinogenesis Female Corrigendum Oxidative stress Research Article medicine.drug Hormone |
| Zdroj: | BioMed Research International, Vol 2017 (2017) BioMed Research International |
| ISSN: | 2314-6133 |
| DOI: | 10.1155/2017/4176170 |
| Popis: | Ionizing radiation may cause irreversible ovarian failure, which, therefore, calls for an effective radioprotective reagent. The aim of the present study was to evaluate the potential radioprotective effect of N-acetylcysteine (NAC) on ionizing radiation induced ovarian failure and loss of ovarian reserve in mice. Kun-Ming mice were either exposed to X-irradiation (4 Gy), once, and/or treated with NAC (300 mg/kg), once daily for 7 days before X-irradiation. We examined the serum circulating hormone levels and the development of ovarian follicles as well as apoptosis, cell proliferation, and oxidative stress 24 hours after X-irradiation. In addition, morphological observations on the endometrial luminal epithelium and the fertility assessment were performed. We found that NAC successfully restored the ovarian and uterine function, enhanced the embryo implantation, improved the follicle development, and altered the abnormal hormone levels through reducing the oxidative stress and apoptosis level in granulosa cells while promoting the proliferation of granulosa cells. In conclusion, the radioprotective effect of NAC on mice ovary from X-irradiation was assessed, and our results suggested that NAC can be a potential radioprotector which is capable of preventing the ovarian failure occurrence and restoring the ovarian reserve. |
| Databáze: | OpenAIRE |
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