The effect of atropine in vasovagal syncope induced by head-up tilt testing
| Autor: | G Gentilucci, Fabrizio Ammirati, Furio Colivicchi, Vincenzo Guido, Massimo Santini |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Atropine
Male Posture Hemodynamics Placebo law.invention Bolus (medicine) Randomized controlled trial Tilt-Table Test law Reflex Heart rate Syncope Vasovagal Humans Medicine Single-Blind Method Vasovagal syncope business.industry Parasympatholytics Vagus Nerve Middle Aged medicine.disease Anesthesia Injections Intravenous Ambulatory Electrocardiography Ambulatory Female Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | European Heart Journal. 20:1745-1751 |
| ISSN: | 0195-668X |
| Popis: | Aims This single-blinded, randomized, placebo-controlled study was designed and undertaken to assess the efficacy of intravenous atropine administration on haemodynamic impairment induced by head-up tilt testing in patients with vasovagal syncope. Methods and Results One hundred and thirteen consecutive patients (62 male and 51 female, mean age 46·3 years) with recurrent syncope, no evidence of cardiac, neurological or metabolic disease and a positive head-up tilt test were included in the study. Within 2 weeks of the first head-up tilt test all patients underwent a second tilt test. During this second test, all patients were randomized to receive a bolus of either atropine (0·02mg.kg−1) or placebo (isotonic saline solution). The administration of atropine or placebo was performed at the onset of the haemodynamic modifications (heart rate and/or blood pressure fall) in conjunction with typical vasovagal prodromal symptoms. Treatment was taken as effective when symptoms aborted and the test was completed. In 29 of 113 patients the second tilt test was negative and these patients were excluded from final data analysis. Forty-one patients received placebo, which was effective in nine cases (21·9%). Atropine was administered to 43 patients and was effective in 30 cases (69·7%, P |
| Databáze: | OpenAIRE |
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