Chemopreventive efficacy of oral curcumin: a prodrug hypothesis

Autor:	Jayanth Panyam, Alex E. Grill, Vidhi Khanna, Ameya R. Kirtane, Garvey Liu
Rok vydání:	2019
Předmět:	0301 basic medicine Curcumin Administration Oral Mice Nude Breast Neoplasms Pharmacology Biochemistry 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Drug Delivery Systems Glucuronides Oral administration Cell Line Tumor Genetics medicine Animals Humans Prodrugs Molecular Biology Glucuronidase Mice Inbred BALB C Chemistry Research Cancer Prodrug medicine.disease Bioavailability 030104 developmental biology Mechanism of action Polyphenol Female medicine.symptom Glucuronide 030217 neurology & neurosurgery Biotechnology
Zdroj:	FASEB J
ISSN:	1530-6860
Popis:	Oral consumption of curcumin, a natural polyphenol, is associated with reduced incidence of cancer. Yet, a significant amount of the orally dosed compound is eliminated in the feces, and a major fraction of the absorbed compound is metabolized to inactive glucuronides, resulting in poor bioavailability (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a11879208430b6a3d44ccedfe6c4eef https://pubmed.ncbi.nlm.nih.gov/31136203 Zobrazit plný text záznamu Plný text