Assessing the Subjective and Physiological Effects of Intranasally Administered Crushed Extended-Release Morphine Formulations with and without a Sequestered Naltrexone Core in Recreational Opioid Users
| Autor: | Veeraindar Goli, Ira Smith, Beatrice Setnik, Naama Levy-Cooperman, Megan J. Shram, Catherine Mills |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Naltrexone Hydrochloride Chemistry Pharmaceutical Emotions Placebo Naltrexone Cohort Studies Young Adult Double-Blind Method medicine Humans Administration Intranasal lcsh:R5-920 Cross-Over Studies Morphine Illicit Drugs business.industry Pupil Middle Aged Crossover study Analgesics Opioid Treatment Outcome Anesthesiology and Pain Medicine Neurology Opioid Delayed-Action Preparations Pharmacodynamics Anesthesia Female Original Article Nasal administration lcsh:Medicine (General) business medicine.drug |
| Zdroj: | Pain Research and Management, Vol 18, Iss 4, Pp e55-e62 (2013) |
| ISSN: | 1203-6765 |
| DOI: | 10.1155/2013/952082 |
| Popis: | OBJECTIVE: To evaluate the pharmacodynamic (PD) effects of morphine sulfate and naltrexone hydrochloride extended-release (MSN) capsules compared with controlled-release morphine sulfate (MS) and placebo when crushed and administered intranasally.METHODS: The present study was a randomized, double-blinded, placebo-controlled, single-dose (30 mg), three-way crossover study in healthy, nondependent recreational opioid users. PD measures included assessment of subjective drug effects using visual analogue scales (VAS) ranging from 0 to 100 and assessments of pupil diameter. Blood samples were collected for pharmacokinetic analyses.RESULTS: Both MS and MSN showed significantly higher PD values compared with placebo. MSN showed significantly lower scores for drug liking and high VAS scores on both mean peak effect (Emax) (69.6 and 55.2, respectively) and in area under the effect curve over 2 h (86.3 and 66.7, respectively) following dosing compared with MS (Emax87.6 and 86.6, respectively; area under the curve over 2 h 120.6 and 132.9, respectively; Pmaxfor all other positive subjective effects (good drug effects, overall drug liking, and take drug again VAS scores) compared with MS (Pmax) and median time to Cmaxfor morphine following administration of MSN and MS were similar (27.3 ng/mL and 0.57 h versus 27.7 ng/mL and 0.6 h, respectively). Naltrexone mean Cmaxwas 1497 pg/mL after MSN and median time to Cmaxwas 0.55 h.CONCLUSIONS: When crushed and administered intranasally, MSN was associated with significantly lower ratings of drug liking and other positive subjective effects compared with MS. |
| Databáze: | OpenAIRE |
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