Green banana flour supplementation improves obesity-associated systemic inflammation and regulates gut microbiota profile in mice fed high-fat diets
| Autor: | Alessandra da Rocha Pinheiro Mulder, Nathália Moura-Nunes, Elisa B. Monteiro, Carolyne Pimentel Rosado, André Almo, Julio Beltrame Daleprane, Victor Hugo Cordeiro Rosa, Bruna Cadete Martins, Aruanna Cajaty Soares |
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| Rok vydání: | 2021 |
| Předmět: |
Leptin
Male food.ingredient Physiology Endocrinology Diabetes and Metabolism Mice Obese engineering.material Biology Gut flora Diet High-Fat Weight Gain Systemic inflammation chemistry.chemical_compound food Functional food Physiology (medical) Adipocyte medicine Animals Obesity Food science Resistant starch Adiposity Inflammation Nutrition and Dietetics Interleukin-6 Tumor Necrosis Factor-alpha Pulp (paper) Musa High fat diet General Medicine medicine.disease biology.organism_classification Gastrointestinal Microbiome Mice Inbred C57BL Disease Models Animal chemistry Food Fortified engineering medicine.symptom |
| Zdroj: | Applied Physiology, Nutrition, and Metabolism. 46:1469-1475 |
| ISSN: | 1715-5320 1715-5312 |
| Popis: | This study evaluated the effect of green banana flour (GBF) consumption on obesity-related conditions in mice fed high-fat diets. GBF was prepared using stage 1 green banana pulp, which was dehydrated and milled. Mice were fed a control diet (n = 20; 10% of energy from lipids) or a high-fat diet (n = 20; 50% of energy from lipids). After 10 weeks, mice were divided into 4 groups based on feed: standard chow (SC; n = 10), standard with 15% GBF (SB; n = 10), high-fat diet (HF; n = 10) and high-fat diet with 15% GBF (HFB; n = 10) for 4 weeks. HFB exhibited lower gains in body weight (–21%; p < 0.01) and in all fat pads (p < 0.01) compared with the HF group. SC, SB, and HFB showed smaller retroperitoneal white adipose tissue diameters (p < 0.001). SB and HFB-treated mice showed lower levels of leptin, IL-6, and TNF-α compared with the SC and HF groups (p < 0.01). In the GBF-fed groups, there was a reduction in the abundance of Firmicutes (SB: –22%; HFB: –23%) and an increase in Bacteroidetes (SB: +25%; HFB: +29%) compared with their counterparts. We demonstrated that GBF consumption attenuated inflammation and improved metabolic status, adipose tissue remodeling, and the gut microbiota profile of obese mice. Novelty: Green banana flour (GBF) consumption, rich in resistant starch, regulates body weight in mice fed high-fat diets. GBF consumption improves fat pad distribution in mice fed high-fat diets. GBF improves obesity-associated systemic inflammation and regulates gut microbiota profile in mice fed high-fat diets. |
| Databáze: | OpenAIRE |
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