The consequences of risk reducing salpingo-oophorectomy: the case for a coordinated approach to long-term follow up post surgical menopause
Autor: | Paul A. James, Joanne McKinley, Mary-Anne Young, Mary Shanahan, Gillian Mitchell, Carmel Pezaro |
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Rok vydání: | 2012 |
Předmět: |
Cancer Research
medicine.medical_specialty Cross-sectional study Ovariectomy medicine.medical_treatment Gene mutation Prophylactic Oophorectomy Breast cancer Quality of life Surveys and Questionnaires Genetics medicine Humans Genetic Predisposition to Disease Salpingostomy Osteoporosis Postmenopausal Genetics (clinical) BRCA2 Protein Gynecology BRCA1 Protein business.industry Obstetrics Hormone replacement therapy (menopause) Middle Aged medicine.disease Menopause Cross-Sectional Studies Sexual dysfunction Premenopause Oncology Mutation Female medicine.symptom business Risk Reduction Behavior Follow-Up Studies |
Zdroj: | Familial Cancer. 11:403-410 |
ISSN: | 1573-7292 1389-9600 |
Popis: | Women with germline mutations in BRCA1 and BRCA2 genes have significantly increased lifetime risks of breast and ovarian cancer. To manage both the ovarian and breast cancer risks the current recommendation is undergo a risk reducing salpingo-oophorectomy (RRSO) prior to natural menopause. To date, studies have focussed on quality of life and sexual dysfunction in women who undergo RRSO, but few have reported on the wider physical consequences. We performed a questionnaire study in women with BRCA 1 or 2 gene mutations known to the Peter MacCallum Familial Cancer Centre. We gathered information about ovarian surgery, ongoing follow-up, management of risk factors including osteoporosis, and current severity of menopausal symptoms. Two hundred and nineteen women were surveyed. One hundred and forty-three of 157 responding participants (91 %) reported having RRSO. Sixty one were pre-menopausal at RRSO. Post surgical follow-up rates were generally low, and a minority of women reported recent bone density imaging or pharmaceutical prevention or treatment of osteoporosis. Menopausal symptoms appeared generally mild. No significant differences in symptom severity were observed in women who underwent a pre-menopausal RRSO compared to RRSO after natural menopause. These data indicate that a formalised follow-up protocol is necessary to optimally manage the consequences of a RRSO. |
Databáze: | OpenAIRE |
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