Interaction between maropitant and carprofen on sparing of the minimum alveolar concentration for blunting adrenergic response (MAC-BAR) of sevoflurane in dogs
| Autor: | Kenjiro Miyoshi, Mohammed A. Umar, Jun Tamura, Kazuto Yamashita, Tadashi Sano, Sho Fukui, Tomohito Ishizuka, Takaharu Itami, Norihiko Ooyama |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Methyl Ethers Quinuclidines Minimum alveolar concentration 040301 veterinary sciences Premedication medicine.medical_treatment Analgesic Carbazoles sevoflurane Sevoflurane 0403 veterinary science 03 medical and health sciences chemistry.chemical_compound Dogs 0302 clinical medicine Neurokinin-1 Receptor Antagonists medicine Animals Anesthesia Drug Interactions Carprofen Saline Anesthetics Dose-Response Relationship Drug Full Paper General Veterinary maropitant business.industry Anti-Inflammatory Agents Non-Steroidal 04 agricultural and veterinary sciences MAC-BAR Pulmonary Alveoli carprofen chemistry Anesthetics Inhalation Anesthetic dog Drug Therapy Combination Female Surgery Maropitant business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | The Journal of Veterinary Medical Science |
| Popis: | Maropitant, a neurokinin-1 receptor antagonist, may provide analgesic effects by blocking pharmacological action of substance P. Carprofen is a non-steroidal anti-inflammatory drug commonly used for pain control in dogs. The purpose of this study was to evaluate the effect of a combination of maropitant and carprofen on the minimum alveolar concentration for blunting adrenergic response (MAC-BAR) of sevoflurane in dogs. Six healthy adult beagle dogs were anesthetized with sevoflurane four times with a minimum of 7-day washout period. On each occasion, maropitant (1 mg/kg) alone, carprofen (4 mg/kg) alone, a combination of maropitant (1 mg/kg) and carprofen (4 mg/kg), or saline (0.1 ml/kg) was subcutaneously administered at 1 hr prior to the first electrical stimulation for the sevoflurane MAC-BAR determination. The sevoflurane MAC-BAR was significantly reduced by maropitant alone (2.88 ± 0.73%, P=0.010), carprofen alone (2.96 ± 0.38%, P=0.016) and the combination (2.81 ± 0.51%, P=0.0003), compared with saline (3.37 ± 0.56%). There was no significant difference in the percentage of MAC-BAR reductions between maropitant alone, carprofen alone and the combination. The administration of maropitant alone and carprofen alone produced clinically significant sparing effects on the sevoflurane MAC-BAR in dogs. However, the combination of maropitant and carprofen did not produce any additive effect on the sevoflurane MAC-BAR reduction. Anesthetic premedication with a combination of maropitant and carprofen may not provide any further sparing effect on anesthetic requirement in dogs. |
| Databáze: | OpenAIRE |
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