Effects of photobiomodulation therapy on regulation of myogenic regulatory factor mRNA expression in vivo: A systematic review
| Autor: | Benjamin S. Simpson, David W. Shepherd, Darren J. Player, Joseph M. Norris, Hayley C. Whitaker |
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| Rok vydání: | 2021 |
| Předmět: |
Web of science
business.industry Mrna expression Regeneration (biology) General Engineering General Physics and Astronomy Skeletal muscle General Chemistry Muscle Development MyoD Bioinformatics General Biochemistry Genetics and Molecular Biology medicine.anatomical_structure Myogenic Regulatory Factors Laser therapy In vivo Myogenic regulatory factors medicine General Materials Science RNA Messenger Low-Level Light Therapy business |
| Zdroj: | Journal of Biophotonics. 15 |
| ISSN: | 1864-0648 1864-063X |
| DOI: | 10.1002/jbio.202100219 |
| Popis: | Non-invasive promotion of myogenic regulatory factors (MRF), through photobiomodulation therapy (PBMT), may be a viable method of facilitating skeletal muscle regeneration post-injury, given the importance of MRF in skeletal muscle regeneration. The aim of this systematic review was to collate current evidence, identifying key themes and changes in expression of MRF in in vivo models. Web of Science, PubMed, Scopus and Cochrane databases were systematically searched and identified 1,459 studies, of which ten met the inclusion criteria. MyoD was most consistently regulated in response to PBMT treatment, and the expression of remaining MRFs was heterogenous. All studies exhibited a high risk of bias, primarily due to lack of blinding in PBMT application and MRF analysis. Our review suggests that the current evidence base for MRF expression from PBMT is highly variable. Future research should focus on developing a robust methodology for determining the effect of laser therapy on MRF expression, as well as long term assessment of skeletal muscle regeneration. This article is protected by copyright. All rights reserved. |
| Databáze: | OpenAIRE |
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