Regulation of tissue crosstalk by skeletal muscle-derived myonectin and other myokines

Autor: G. William Wong, Marcus M. Seldin
Rok vydání: 2012
Předmět:
Zdroj: Adipocyte, vol 1, iss 4
Adipocyte
ISSN: 2162-397X
2162-3945
DOI: 10.4161/adip.20877
Popis: The integrated control of animal physiology requires intimate tissue crosstalk, a vital task mediated by circulating humoral factors. As one type of these factors, adipose tissue-derived adipokines have recently garnered attention as important regulators of systemic insulin sensitivity and metabolic homeostasis. However, the realization that skeletal muscle also secretes a variety of biologically and metabolically active polypeptide factors (collectively called myokines) has provided a new conceptual framework to understand the critical role skeletal muscle plays in coordinating whole-body energy balance. Here, we highlight recent progress made in the myokine field and discuss possible roles of myonectin, which we have recently identified as a potential postprandial signal derived from skeletal muscle to integrate metabolic processes in other tissues, such as adipose and liver; one of its roles is to promote fatty acid uptake into cells. Myonectin is also likely an important mediator in inter-tissue crosstalk.
Databáze: OpenAIRE