Regulation of tissue crosstalk by skeletal muscle-derived myonectin and other myokines
Autor: | G. William Wong, Marcus M. Seldin |
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Rok vydání: | 2012 |
Předmět: |
medicine.medical_specialty
Histology Mini Review Adipokine Adipose tissue 030209 endocrinology & metabolism Biology fatty acids myokine 03 medical and health sciences 0302 clinical medicine Mediator lipid uptake Internal medicine Myokine medicine skeletal muscle 030304 developmental biology FABP 0303 health sciences Insulin sensitivity Skeletal muscle Cell Biology myonectin energy balance CTRP15 Cell biology Crosstalk (biology) FATP Endocrinology medicine.anatomical_structure Myonectin |
Zdroj: | Adipocyte, vol 1, iss 4 Adipocyte |
ISSN: | 2162-397X 2162-3945 |
DOI: | 10.4161/adip.20877 |
Popis: | The integrated control of animal physiology requires intimate tissue crosstalk, a vital task mediated by circulating humoral factors. As one type of these factors, adipose tissue-derived adipokines have recently garnered attention as important regulators of systemic insulin sensitivity and metabolic homeostasis. However, the realization that skeletal muscle also secretes a variety of biologically and metabolically active polypeptide factors (collectively called myokines) has provided a new conceptual framework to understand the critical role skeletal muscle plays in coordinating whole-body energy balance. Here, we highlight recent progress made in the myokine field and discuss possible roles of myonectin, which we have recently identified as a potential postprandial signal derived from skeletal muscle to integrate metabolic processes in other tissues, such as adipose and liver; one of its roles is to promote fatty acid uptake into cells. Myonectin is also likely an important mediator in inter-tissue crosstalk. |
Databáze: | OpenAIRE |
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