Epidemiology of multiple congenital anomalies in Europe : A EUROCAT population-based registry study

Autor: Kari Klungsøyr, Joan K. Morris, Amanda J. Neville, Helen Dolk, Hermien E. K. de Walle, Judith Rankin, Elisa Calzolari, Anke Rissmann, Babak Khoshnood, Larraitz Arriola, Fabrizio Bianchi, Annette Queisser-Luft, Ingeborg Barišić, Maria Loane, Marie-Claude Addor, Diana Wellesley, Judith L. S. Budd, Vera Nelen, Christine Verellen-Dumoulin, Catherine Rounding, Bob McDonnell, Ester Garne, David Tucker
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Male
Embryology
Pediatrics
Epidemiology
Prenatal diagnosis
INFANTS
Pregnancy
Prevalence
Medicine
Registries
education.field_of_study
Automatic Data Processing
General Medicine
Classification
Multiple congenital anomalies
Computer algorithm
Europe
classification
cardiovascular system
Female
epidemiology
Population-Based Registry
Algorithms
circulatory and respiratory physiology
medicine.medical_specialty
Population
prevalence
multiple congenital anomalies
BIRTH-DEFECTS
Humans
Abnormalities
Multiple
MALFORMATIONS
RATES
cardiovascular diseases
education
Retrospective Studies
Electronic Data Processing
prenatal diagnosis
business.industry
Public health
Retrospective cohort study
medicine.disease
nervous system diseases
Pediatrics
Perinatology and Child Health
PATTERNS
business
Developmental Biology
Zdroj: Birth Defects Research. Part A: Clinical and Molecular Teratology, 100(4), 270-276. Wiley-Blackwell
Calzolari, E, Barisic, I, Loane, M, Morris, J, Wellesley, D, Dolk, H, Addor, M-C, Arriola, L, Bianchi, F, Neville, A J, Budd, J L S, Klungsoyr, K, Khoshnood, B, McDonnell, B, Nelen, V, Queisser-Luft, A, Rankin, J, Rissmann, A, Rounding, C, Tucker, D, Verellen-Dumoulin, C, de Walle, H & Garne, E 2014, ' Epidemiology of multiple congenital anomalies in Europe: A EUROCAT population-based registry study ', Birth Defects Research. Part A: Clinical and Molecular Teratology, vol. 100, no. 4, pp. 270-276 . https://doi.org/10.1002/bdra.23240
ISSN: 1542-0752
DOI: 10.1002/bdra.23240
Popis: BACKGROUND: This study describes the prevalence, associated anomalies, and demographic characteristics of cases of multiple congenital anomalies (MCA) in 19 population-based European registries (EUROCAT) covering 959,446 births in 2004 and 2010.METHODS: EUROCAT implemented a computer algorithm for classification of congenital anomaly cases followed by manual review of potential MCA cases by geneticists. MCA cases are defined as cases with two or more major anomalies of different organ systems, excluding sequences, chromosomal and monogenic syndromes.RESULTS: The combination of an epidemiological and clinical approach for classification of cases has improved the quality and accuracy of the MCA data. Total prevalence of MCA cases was 15.8 per 10,000 births. Fetal deaths and termination of pregnancy were significantly more frequent in MCA cases compared with isolated cases (p CONCLUSION: Although rare, MCA cases are an important public health issue, because of their severity. The EUROCAT database of MCA cases will allow future investigation on the epidemiology of these conditions and related clinical and diagnostic problems.
Databáze: OpenAIRE
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