Polysaccharide from tuberous roots of Ophiopogon japonicus regulates gut microbiota and its metabolites during alleviation of high-fat diet-induced type-2 diabetes in mice
| Autor: | Etta Y. L. Liu, Lin-Xiu Guo, Cheng Wang, Karl Wah Keung Tsim, Ting Xia Dong, Huaiyou Wang, Tiejie Wang, Chen Zhicong, Wei-Hui Hu, Zhi-Tian Peng |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Ophiopogon japonicus Medicine (miscellaneous) Type 2 diabetes Gut microbiota Gut flora Microbiology 03 medical and health sciences Short-chain fatty acids 0404 agricultural biotechnology Insulin resistance Functional food Polysaccharides medicine TX341-641 Bifidobacterium Type-2 diabetes 030109 nutrition & dietetics Nutrition and Dietetics biology Nutrition. Foods and food supply Metabolic disorder digestive oral and skin physiology food and beverages 04 agricultural and veterinary sciences biology.organism_classification medicine.disease 040401 food science Dysbiosis Food Science |
| Zdroj: | Journal of Functional Foods, Vol 63, Iss, Pp-(2019) |
| ISSN: | 1756-4646 |
| Popis: | Ophiopogonis Radix (Maidong in Chinese), the tuberous roots of Ophiopogon japonicus having polysaccharide as the main active ingredient, is a traditional Chinese herb and popularly used as functional food additive in China. Here, a homogeneous polysaccharide fraction (OJP-W1) was isolated and characterized from Ophiopogonis Radix collected from Sichuan (Chuan-Maidong). The therapeutic effects of OJP-W1 in diabetes symptoms, gut microbiota and metabolism of short-chain fatty acids (SCFAs) in high-fat diet (HFD)-induced type-2 diabetes mice were investigated. Results showed that OJP-W1 significantly ameliorated HFD-induced insulin resistance and glucose tolerance. Meanwhile, OJP-W1 regulated the gut microbiota dysbiosis in HFD-fed mice, as indicated by increasing Actinobacteria and Bifidobacterium, decreasing Proteobacteria and type-2 diabetes-enriched taxa (e.g. Desulfovibrionaceae, Dorea and Ruminococcaceae). In addition, OJP-W1 could improve the metabolic disorder of SCFAs in HFD-fed mice. This study indicated that OJP-W1 might serve as a novel functional food in preventing diabetes-associated gut microbiota dysbiosis and SCFA metabolic disorder. |
| Databáze: | OpenAIRE |
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