Corticotropin-independent effect of ovine corticotropin-releasing hormone on cortisol release in man
| Autor: | J.C. Melby, A. Turner, S.T. Azar |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Blood Glucose Male endocrine system medicine.medical_specialty Hydrocortisone Corticotropin-Releasing Hormone medicine.medical_treatment Hypoglycemia Corticotropin-releasing hormone Adrenocorticotropic Hormone Internal medicine medicine Humans Insulin business.industry General Medicine Metabolism Middle Aged medicine.disease Endocrinology Healthy individuals Reserve capacity Female business hormones hormone substitutes and hormone antagonists medicine.drug Hormone |
| Zdroj: | The American journal of the medical sciences. 303(4) |
| ISSN: | 0002-9629 |
| Popis: | The effect of corticotropin-releasing hormone (CRH), independent of adrenocorticotropin hormone (ACTH), was evaluated in nine healthy individuals. Cortisol release and corresponding ACTH production were determined after separate intravenous administration of ovine-CRH (1 micrograms/kg BW) and insulin inducing hypoglycemia (0.1 u/kg BW). Adrenocorticotropin hormone (1-24; 250 micrograms intravenous bolus) revealed an adequate adrenal reserve capacity in all subjects. At the time of peak cortisol response following CRH and insulin administration, IR-cortisol increments were 14 +/- 1 micrograms/dl and 9 +/- 1 micrograms/dl (mean +/- SE), respectively (p less than .05); whereas ACTH (IR-ACTH) increments were 40 +/- 10 ng/l and 53 +/- 14 ng/l, respectively. The cortisol increment/ACTH increment ratios were 0.53 +/- 0.09 and 0/36 +/- 0.09, respectively (p less than 0.05), suggesting an ACTH-independent effect of CRH on cortisol production. The authors speculate that CRH may have a direct effect on the human adrenal gland or it may release ACTH-like factors that stimulate the human adrenal cortex. |
| Databáze: | OpenAIRE |
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