Chemotherapy does not nullify the ability of donor lymphocyte infusions to mediate graft-versus-host reactions
| Autor: | V Altomonte, Susan K. Wright, Georgia B. Vogelsang, R L Humphrey, Hayden G. Braine, Ephraim J. Fuchs, A. Seber, K G Schepers, S. J. Noga, Richard J. Jones |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Male medicine.medical_specialty Lymphocyte Transfusion Lymphocyte medicine.medical_treatment Graft vs Host Disease Gastroenterology immune system diseases Recurrence hemic and lymphatic diseases Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Transplantation Homologous Lymphocytes Multiple myeloma Bone Marrow Transplantation Transplantation Chemotherapy business.industry Graft vs Tumor Effect Hematology Middle Aged medicine.disease Donor Lymphocytes Tissue Donors surgical procedures operative medicine.anatomical_structure Graft-versus-host disease Immunology Female Bone marrow business Multiple Myeloma Plasmacytoma |
| Zdroj: | Bone marrow transplantation. 22(3) |
| ISSN: | 0268-3369 |
| Popis: | Two patients with multiple myeloma in relapse after allogeneic BMT received donor lymphocyte infusions (DLI) but later required chemotherapy for treatment of myeloma-related complications. In both patients, recovery from chemotherapy-induced aplasia was accompanied by manifestations of graft-versus-host reactions. The first patient developed grade II acute GVHD and a complete remission which has lasted >22 months. The second patient developed grade III acute GVHD but died with co-existing GVHD and extensive extramedullary myeloma. These results demonstrate that chemotherapy does not nullify the ability of donor lymphocytes to mediate graft-versus-host reactions. |
| Databáze: | OpenAIRE |
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