Erratum: Effects of growth hormone treatment on growth plate, bone, and mineral metabolism of young rats with uremia induced by adenine
| Autor: | Rocío Fuente, Flor A. Ordoñez, Fernando Santos, Enrique García-López, Julián Rodríguez-Suárez, Olaya Hernández Frías, Helena Gil-Peña, Débora Claramunt |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Fibroblast growth factor 23 Vascular Endothelial Growth Factor A medicine.medical_specialty Normal diet medicine.medical_treatment 030232 urology & nephrology Parathyroid hormone Chondrocyte hypertrophy Chondrocyte Blood Urea Nitrogen Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Chondrocytes Internal medicine medicine Animals Growth Plate Uremia Inflammation Minerals Chemistry Growth factor Adenine X-Ray Microtomography Rats Vascular endothelial growth factor Growth hormone treatment Fibroblast Growth Factors 030104 developmental biology medicine.anatomical_structure Endocrinology Parathyroid Hormone Growth Hormone Pediatrics Perinatology and Child Health Female |
| Zdroj: | Pediatric Research. 82:888-888 |
| ISSN: | 1530-0447 0031-3998 |
| DOI: | 10.1038/pr.2017.205 |
| Popis: | BackgroundIn a model of growth retardation secondary to chronic kidney disease (CKD) induced by adenine, this study explores the effects of growth hormone (GH) therapy on growth plate and mineral metabolism.MethodsWeaning female rats receiving a 0.5% adenine diet during 21 days, untreated (AD) or treated with GH (ADGH) for 1 week, were compared with control rats receiving normal diet, either ad libitum or pair-fed with AD animals. AD and ADGH rats had similarly elevated serum concentrations of urea nitrogen, parathyroid hormone (PTH), and fibroblast growth factor 23 (FGF23).ResultsUremia induced by adenine caused growth retardation and disturbed growth cartilage chondrocyte hypertrophy. We demonstrated marked expression of aquaporin 1 in the growth plate, but its immunohistochemical signal and the expression levels of other proteins potentially related with chondrocyte enlargement, such as Na-K-2Cl cotransporter, insulin-like growth factor 1 (IGF-1), and IGF-1 receptor, were not different among the four groups of rats. The distribution pattern of vascular endothelial growth factor was also similar. AD rats developed femur bone structure abnormalities analyzed by micro-computerized tomography.ConclusionGH treatment accelerated longitudinal growth velocity, stimulated the proliferation and enlargement of chondrocytes, and did not modify the elevated serum PTH or FGF23 concentrations or the abnormal bone structure. |
| Databáze: | OpenAIRE |
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