Pediatric sleep apnea: Characterization of apneic events and sleep stages using heart rate variability

Autor: Adrián Martín-Montero, Pablo Armañac-Julián, Eduardo Gil, Leila Kheirandish-Gozal, Daniel Álvarez, Jesús Lázaro, Raquel Bailón, David Gozal, Pablo Laguna, Roberto Hornero, Gonzalo C. Gutiérrez-Tobal
Rok vydání: 2023
Předmět:
Zdroj: Computers in Biology and Medicine. 154:106549
ISSN: 0010-4825
DOI: 10.1016/j.compbiomed.2023.106549
Popis: Producción Científica
Heart rate variability (HRV) is modulated by sleep stages and apneic events. Previous studies in children compared classical HRV parameters during sleep stages between obstructive sleep apnea (OSA) and controls. However, HRV-based characterization incorporating both sleep stages and apneic events has not been conducted. Furthermore, recently proposed novel HRV OSA-specific parameters have not been evaluated. Therefore, the aim of this study was to characterize and compare classic and pediatric OSA-specific HRV parameters while including both sleep stages and apneic events. A total of 1610 electrocardiograms from the Childhood Adenotonsillectomy Trial (CHAT) database were split into 10-minute segments to extract HRV parameters. Segments were characterized and grouped by sleep stage (wake, W; non-rapid eye movement, NREMS; and REMS) and presence of apneic events (under 1 apneic event per segment, e/s; 1–5 e/s; 5–10 e/s; and over 10 e/s). NREMS showed significant changes in HRV parameters as apneic event frequency increased, which were less marked in REMS. In both NREMS and REMS, power in BW2, a pediatric OSA-specific frequency domain, allowed for the optimal differentiation among segments. Moreover, in the absence of apneic events, another defined band, BWRes, resulted in best differentiation between sleep stages. The clinical usefulness of segment-based HRV characterization was then confirmed by two ensemble-learning models aimed at estimating apnea-hypopnea index and classifying sleep stages, respectively. We surmise that basal sympathetic activity during REMS may mask apneic events-induced sympathetic excitation, thus highlighting the importance of incorporating sleep stages as well as apneic events when evaluating HRV in pediatric OSA.
Ministerio de Ciencia, Innovación y Universidades y el Fondo Europeo de Desarrollo Regional (FEDER) under projects (PID2019-104881RB-I00), (PID2020-115468RB-I00), (PDC2021-120775-I00) and (PID2021-126734OB-C21)
Sociedad Española de Sueño (SES) en el marco del proyecto “Beca de Investigación SES 2019”, by 'CIBER-Consorcio Centro de Investigación Biomédica en Red- (CB19/01/00012)' a través del 'Instituto de Salud Carlos III' co- financiado con fondos FEDER, así como bajo el proyecto SleepyHeart de la convocatoria de valorización 2020, y por el Gobierno de Aragón (Grupo de Referencia BSICoS T39-20R).
The National Sleep Research Resource was supported by the National Heart, Lung, and Blood Institute (R24 HL114473, 75N92019R002).
Ministerio de Ciencia, Innovación y Universidades, “Ayudas para contratos predoctorales para la Formación de Doctores” grant (PRE2018-085219) and “Ramón y Cajal” (MICIU/FSE) grant (RYC2019-028566-I)
Institutos Nacionales de Salud-"Ensayo de adenoamigdalectomía infantil (CHAT)"- (HL083075, HL083129, UL1-RR-024134, UL1 RR024989) and (grant AG061824).
Databáze: OpenAIRE
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