Mechanisms of Photoinduced Cochlear Ischemia in the Guinea Pig
| Autor: | Jin Kanzaki, Yasuhiro Inoue, Kaoru Ogawa, Hideyuki Saito, Noriyuki Hoya, Tatsuhiko Harada |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Pathology
medicine.medical_specialty Guinea Pigs Ischemia Guinea pig chemistry.chemical_compound Evoked Potentials Auditory Brain Stem otorhinolaryngologic diseases medicine Rose bengal Animals Cochlea Rose Bengal Photosensitizing Agents business.industry Stria Vascularis medicine.disease Disease Models Animal Modiolus (cochlea) Auditory brainstem response Otorhinolaryngology chemistry Spiral ligament Systemic administration Biophysics sense organs business Photic Stimulation |
| Zdroj: | ORL. 63:148-154 |
| ISSN: | 1423-0275 0301-1569 |
| Popis: | An experimental model of cochlear ischemia using the photosensitization reaction of rose bengal (RB) is reported. Ischemia was induced by the systemic administration of RB solution and localized irradiation of the cochlea with a green light of specific wavelength for RB activation. After the RB solution was administered, the cochlear blood flow was temporarily increased and then decreased, and the latency of wave I of the auditory brainstem response increased and the amplitude of wave I decreased after RB injection and finally wave I disappeared completely. A histological study revealed thrombus formation in the vessels of the irradiated cochlea not only in the stria vascularis and the spiral ligament, but also in the modiolus. L-Histidine, a scavenger of singlet oxygen (1O2) and hydroxyl radical (·OH), significantly prolonged cochlear dysfunction, but D-mannitol, a specific scavenger of ·OH did not, suggesting that 1O2 has an important role in this reaction. |
| Databáze: | OpenAIRE |
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