IntestinalFABP2A54T Polymorphism: Association with Insulin Resistance and Obesity in Women
| Autor: | Claudio Liberman, Cecilia Albala, Mariana Cifuentes, José Luis Santos, Ana Claudia Villarroel, Bárbara Angel, Lydia Lera, Francisco Pérez-Bravo |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Threonine medicine.medical_specialty Genotype Endocrinology Diabetes and Metabolism medicine.medical_treatment Medicine (miscellaneous) Fatty Acid-Binding Proteins Body Mass Index Endocrinology Insulin resistance Gene Frequency Internal medicine Fatty acid binding medicine Humans Obesity Allele Alleles Alanine Polymorphism Genetic Tumor Necrosis Factor-alpha business.industry Leptin Insulin Public Health Environmental and Occupational Health Middle Aged medicine.disease Female Insulin Resistance Carrier Proteins business Polymorphism Restriction Fragment Length Homeostasis Food Science |
| Zdroj: | OBESITY RESEARCH Artículos CONICYT CONICYT Chile instacron:CONICYT |
| ISSN: | 1071-7323 |
| DOI: | 10.1038/oby.2004.42 |
| Popis: | Objective: To assess the association between the Ala54Thr genetic polymorphism of the fatty acid-binding protein 2 (FABP2) gene with insulin resistance and obesity. Research Methods and Procedures: According to a sampling scheme based on BMI, 33 adult obese women (BMI ≥ 30) and 30 adult normal-weight women (BMI > 18.5 and < 25 kg/m2) were recruited for this study. Women with chronic inflammatory diseases or acute pathology were excluded. Glucose, insulin, leptin, lipids, and tumor necrosis factor α (TNFα) were measured in fasting plasma samples. Insulin resistance was estimated through the homeostasis model assessment for insulin resistance method. The Ala54Thr allelic variant was determined by polymerase chain reaction, followed by restriction fragment-length polymorphism analysis. Results: The Thr54 allele was more frequent in obese than in nonobese women (47.0% vs. 31.7; p = 0.08). Among obese women, higher TNFα concentrations were found when comparing the Thr54/Thr54 genotype (30.0 ± 7.1 pg/mL) with either the Ala54/Thr54 genotype (21.2 ± 8.4 pg/mL) or the Ala54/Ala44 genotype (20.1 ± 7.0 pg/mL) (p < 0.05). In addition, higher fasting plasma insulin and leptin levels were found among Thr54/Thr54 homozygotes compared with the other genotypes (p < 0.05). Discussion: Our results suggest that the Ala54Thr polymorphism of the FABP2 gene is associated with obesity and insulin resistance. The effect of this polymorphism might be mediated by elevated production of TNFα. |
| Databáze: | OpenAIRE |
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