Efficacy of a probiotic supplement in patients with atopic dermatitis: a randomized, double-blind, placebo-controlled clinical trial
| Autor: | Marta Pisati, Angela Michelotti, Ileana De Ponti, Silvana Giardina, Eleonora Spartà, Francesco Tursi, Enza Cestone |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Erythema Dermatology Placebo Severity of Illness Index Gastroenterology Dermatitis Atopic law.invention Desquamation Probiotic Double-Blind Method Randomized controlled trial law Skin Physiological Phenomena Internal medicine medicine Edema Humans SCORAD integumentary system medicine.diagnostic_test Tumor Necrosis Factor-alpha business.industry Probiotics Pruritus Atopic dermatitis medicine.disease Water Loss Insensible Self Concept Cytokines Itching Female Chemokine CCL17 Symptom Assessment medicine.symptom business |
| Zdroj: | European Journal of Dermatology. 31:225-232 |
| ISSN: | 1952-4013 1167-1122 |
| Popis: | Background Atopic dermatitis (AD) is a multifactorial long-standing inflammatory skin disease with a high incidence worldwide in both adults and children. According to the recognized correlation between skin and intestine-the so-called "gut-skin axis"-gut unbalances can affect skin by inducing systemic inflammation and triggering dermatological diseases such as AD. Objectives To evaluate the efficacy of a food supplement containing selected strains of probiotics in ameliorating AD symptoms and skin conditions in adult volunteers. Materials & methods Eighty adult subjects showing mild-to-severe AD, skin dryness, desquamation, erythema and itching were enrolled in a randomized controlled trial to receive, for 56 days, a placebo or a mixture of lactobacilli (L. plantarum PBS067, L. reuteri PBS072 and L. rhamnosus LRH020). The latter was chosen according to the patients' production of post-biotic metabolites and B-group vitamins, anti-inflammatory and anti-oxidant capacity and anti-microbial activity. Clinical and instrumental dermatological evaluation was performed at T0d, T28d and T56d, and then at T84d (after a one-month wash-out). Inflammatory cytokine levels from skin tape stripping, sampled close to AD lesions at T0d and T56d, were also measured. Results Subjects receiving the probiotic mixture showed an improvement in skin smoothness, skin moisturization, self-perception, and a decrease in SCORAD index as well as in the levels of inflammatory markers associated with AD at T28d, with a positive trend up to T56d which was maintained at T84d. Conclusions Administration of selected probiotic strains resulted in a fast and sustained improvement in AD-related symptoms and skin conditions. |
| Databáze: | OpenAIRE |
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