Effects of exogenous transforming growth factor-β1 on spinal cord injury in rats
| Autor: | Kenji Katoh, Takaaki Ikata, Mineo Niwa, Yasuyuki Tsutsumishita, Shinsuke Katoh, Yoshitaka Hamada, Kenji Fukuzawa |
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| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.medical_specialty Central nervous system Drug Evaluation Preclinical Hindlimb Nitric Oxide Subarachnoid Space Cicatrix Transforming Growth Factor beta Internal medicine Animals Medicine RNA Messenger Rats Wistar Spinal cord injury Injections Spinal Spinal Cord Injuries biology business.industry General Neuroscience Anti-Inflammatory Agents Non-Steroidal medicine.disease Spinal cord Pathophysiology Fibronectins Nerve Regeneration Rats Paresis Nitric oxide synthase medicine.anatomical_structure Endocrinology Depression Chemical Enzyme Induction Immunology biology.protein Nitric Oxide Synthase Subarachnoid space business Transforming growth factor |
| Zdroj: | Neuroscience Letters. 203:97-100 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/0304-3940(95)12271-0 |
| Popis: | This study was undertaken to examine the effect of transforming growth factor-beta 1 (TGF-beta 1) administered into the subarachnoid space after spinal cord injury (SCI) on the increased production of inducible-nitric oxide synthase (i-NOS) in the injured spinal cord in rats. The expression of i-NOS mRNA after SCI was remarkably down-regulated by TGF-beta 1 in vivo. Rats treated with TGF-beta 1 showed a better outcome regarding hindlimb motor dysfunction in the first 5 days after injury compared to the saline-treated rats. However, the final outcome was not better and fibrous scar formation in the injured spinal cord was more evident, which was demonstrated as increased immunoreactivity of fibronectin in the later stage after SCI. These results provide evidence of both positive and negative contributions of TGF-beta 1 to the pathology associated with SCI. |
| Databáze: | OpenAIRE |
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