Reconstruction of the Hematopoietic System after Stem Cell Transplantation
| Autor: | N M Blackett, M Y Gordon |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1998 |
| Předmět: |
0301 basic medicine
Neutrophils medicine.medical_treatment Biomedical Engineering Clinical uses of mesenchymal stem cells lcsh:Medicine Hematopoietic stem cell transplantation Models Biological Colony-Forming Units Assay 03 medical and health sciences Leukocyte Count 0302 clinical medicine Medicine Animals Humans Regeneration Progenitor cell Stem cell transplantation for articular cartilage repair Induced stem cells Transplantation business.industry lcsh:R Hematopoietic Stem Cell Transplantation Cell Biology Hematopoietic Stem Cells Endothelial stem cell 030104 developmental biology Cancer research Stem cell business 030217 neurology & neurosurgery Adult stem cell |
| Zdroj: | Cell Transplantation, Vol 7 (1998) |
| ISSN: | 1555-3892 0963-6897 |
| Popis: | The practice of hematopoietic stem cell transplantation to rescue patients from the myeloablative effects of chemo- or radiotherapy, or to replace defective hematopoiesis, is based on the assumption that hematopoietic stem cells in the graft have sufficient proliferative potential to supply mature blood cells for the remainder of the recipient's lifespan. However, the mechanism(s) whereby this is achieved are not well understood. Here we address the reconstruction of the hematopoietic system by considering the effects of stem cell and progenitor cell renewal and differentiation. We conclude that stem cell self-renewal is necessary for hematological recovery and that infused committed progenitor cells (CFU-GM) may contribute to the neutrophil count in the early posttransplant period. |
| Databáze: | OpenAIRE |
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