A rotaxane-based platform for tailoring the pharmacokinetics of cancer-targeted radiotracers

Autor:	Faustine D'Orchymont, Jason Holland
Rok vydání:	2022
Předmět:	General Chemistry
Zdroj:	Chemical Science. 13:12713-12725
ISSN:	2041-6539 2041-6520
DOI:	10.1039/d2sc03928a
Popis:	Radiolabelled monoclonal antibodies (mAbs) are a cornerstone of molecular diagnostic imaging and targeted radioimmunotherapy in nuclear medicine, but one of the major challenges in the field is to identify ways of reducing the radiation burden to patients. We reasoned that a rotaxane-based platform featuring a non-covalent mechanical bond between the radionuclide complex and the biologically active mAb could offer new ways of controlling the biophysical properties of cancer-specific radiotracers for positron emission tomography (PET). Herein, we present the photoradiosynthesis and characterisation of [
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69f6a1348762f062e206a2c437284fcf https://doi.org/10.1039/d2sc03928a Zobrazit plný text záznamu