Structural equation modelling analysis determining causal role among methyltransferases, methylation, and apoptosis during human pregnancy and abortion
| Autor: | Shyam S. Chauhan, Syed Mohd. Fazlur Rehman, Nishat Fatima, Owais Mohammad, Syed Habeeb Ahmed |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult Abortion Habitual Methyltransferase Ursa lcsh:Medicine Apoptosis Biology Abortion Models Biological Article Andrology 03 medical and health sciences Prognostic markers Young Adult Pregnancy medicine Decidua Humans Epigenetics lcsh:Science Fetus Multidisciplinary DNA methylation lcsh:R 0402 animal and dairy science Abortion Induced 04 agricultural and veterinary sciences Methylation Methyltransferases medicine.disease biology.organism_classification 040201 dairy & animal science Pregnancy Trimester First 030104 developmental biology medicine.anatomical_structure Methylation analysis Latent Class Analysis lcsh:Q Female Tumor Suppressor Protein p53 |
| Zdroj: | Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020) |
| ISSN: | 2045-2322 |
| Popis: | The human implantation failure during first trimester leads to spontaneous abortions. Spontaneous abortions are consecutive and occur twice or thrice (with or without prior live births) due to factors which are either maternal or fetal. However, it also constitutes of unknown etiology; known as unexplained recurrent spontaneous abortions (URSA). In this study, the medical terminated human normal early pregnancies (NEP) of the first trimester were taken as control samples, the normal decidual sample whose molecular and epigenetic changes were compared with that of decidua of human URSA subjects. Apoptosis-related genes reported in consecutive recurrent pregnancy loss became the basis for this study. So, in this study, we evaluated the hypothesis that “p53 methylation level through methyltransferases (G9aMT and DNMT1) implicates the fate of embryo towards sustenance or cessation of pregnancy”. Further, the interaction between P53, BAX, BCL-2, CASPASE-6, G9aMT, DNMT-1, and methylated p53 expression level(s) during the first trimester of both URSA and NEP are included in this study. The degree of p53 methylation during the first trimester is found to be significant and positively correlated with that of G9aMT (p p p p-value |
| Databáze: | OpenAIRE |
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