Interleukin 6 as a marker of depression in women with sleep apnea
| Autor: | Miguel Ángel Martínez-García, Francisco Campos-Rodriguez, Verónica Sánchez-López, Maria Isabel Asensio-Cruz, David Gozal, Jose Cordero-Guevara, Angeles Sanchez-Armengol, Elena Arellano-Orden |
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| Přispěvatelé: | Junta de Andalucía, Sociedad Española de Neumología y Cirugía Torácica |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Cognitive Neuroscience Population Interleukin 6 Behavioral Neuroscience Internal medicine Medicine Humans Women education Depression (differential diagnoses) Aged education.field_of_study Sleep Apnea Obstructive business.industry Interleukin-6 Depression Epworth Sleepiness Scale Sleep apnea General Medicine Odds ratio Middle Aged medicine.disease Obstructive sleep apnea Cross-Sectional Studies Cohort Female business Body mass index |
| Zdroj: | Digital.CSIC: Repositorio Institucional del CSIC Consejo Superior de Investigaciones Científicas (CSIC) Digital.CSIC. Repositorio Institucional del CSIC instname |
| Popis: | Depression is common in women with obstructive sleep apnea (OSA), but objective markers of depression have not yet been explored in such patients. We hypothesized that inflammation and antioxidant biomarkers may be associated with depression in a cohort of OSA women. We conducted a multicentre, cross‐sectional study in 247 women diagnosed with moderate‐to‐severe OSA. Depression was assessed by the depression subscale of the Hospital Anxiety and Depression Questionnaire (HAD‐D) and defined as a score ≥11. Associations between tumour necrosis factor α (TNFα), interleukin 6 (IL‐6), C‐reactive protein (CRP), intercellular adhesion molecule 1 (ICAM‐1), catalase (CAT), superoxide dismutase (SOD) and brain‐derived neurotrophic factor (BDNF) plasma levels and depression were assessed. The women had a median (25th‐75th percentiles) age of 58 (51–65) years, body mass index (BMI) of 33.5 (29.0–38.3) Kg/m2, Epworth Sleepiness Scale (ESS) score of 10 (6–13) and apnea–hypopnea index (AHI) of 33.3 (22.8–49.3). Logistic regression analyses revealed that only IL6 levels were associated with the presence of depression (adjusted odds ratio [OR], 1.20; 95% confidence interval [CI], 1.08–1.34), whereas linear regression further confirmed that IL6 levels were significantly associated with HAD‐D scores (β = .154; 95% CI, 0.03–0.30). Multivariate regression analysis showed that IL6 (OR, 1.22; 95% CI, 1.09–1.36), ESS (OR, 1.10; 95% CI 1.02–1.19) and physical activity This study was supported by a grant from the Consejería de Salud de la Junta de Andalucía (PI‐0056‐2016) and a grant from the Sociedad Española de Neumología y Cirugía Torácica SEPAR (19/2016). |
| Databáze: | OpenAIRE |
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