Extended DR3-D6S273-HLA-B haplotypes are associated with increased susceptibility to type 1 diabetes in US Caucasians
| Autor: | Patrick Concannon, Beth Wapelhorst, Glenys Thomson, Ana M. Valdes, Henry A. Erlich, Janelle A. Noble |
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| Rok vydání: | 2005 |
| Předmět: |
musculoskeletal diseases
endocrine system diseases Immunology Human leukocyte antigen Class iii Biology Biochemistry White People HLA-DR3 Antigen European origin immune system diseases HLA-DR4 Antigen Genetics medicine Humans Immunology and Allergy Genetic Predisposition to Disease Allele skin and connective tissue diseases Type 1 diabetes Haplotype General Medicine medicine.disease United States HLA-B Diabetes Mellitus Type 1 Haplotypes HLA-B Antigens Microsatellite |
| Zdroj: | Tissue Antigens. 65:115-119 |
| ISSN: | 1399-0039 0001-2815 |
| DOI: | 10.1111/j.1399-0039.2005.00348.x |
| Popis: | Human leukocyte antigen (HLA)-DR3 haplotypes are associated with susceptibility to type 1 diabetes (T1D). Reports from Northern European populations show that an allele (D6S273*2) at a microsatellite mapping to HLA class III marks an extended DR3-B18 haplotype associated with increased susceptibility to T1D. Consistent with previous reports, D6S273*2 marked a highly predisposing DR3 haplotype in European origin, multiplex families from the USA. Furthermore, we observed on DR3 haplotypes that other D6S273 alleles were also significantly associated with both increased transmission (D6S273*5; P |
| Databáze: | OpenAIRE |
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